PMID: 1357294Oct 10, 1992Paper

Long-term symptomless HIV-1 infection in recipients of blood products from a single donor

Lancet
J C LearmontD Cooper

Abstract

There have been reported cases of long-term symptomless human immunodeficiency virus type 1 (HIV-1) infection, but it is not clear whether the benign course of infection was due to host, viral, or other unknown factors. During follow-up of subjects with transfusion-acquired HIV-1 infection in New South Wales, Australia, we identified a group of 6 subjects who had been infected through a single common donor. We were therefore able to study the contributions of various factors to the course of infection. Throughout follow-up (range 6.8-10.1 years after infection), 5 of the recipients and the donor (last follow-up 10.2 years after infection of the first recipient) remained clinically free of symptoms, with normal CD4 cell counts and no p24 antigenaemia. HIV-1 was isolated from only 1 recipient; the isolate did not induce syncytia in a SUPT1 co-culture assay and had a limited in-vitro host range. 1 infected recipient (who had received extensive immunosuppressive treatment for systemic lupus erythematosus) developed Pneumocystis carinii pneumonia and died 4.3 years after infection. The frequency of progression to AIDS or a CD4 cell count below 0.50 x 10(9)/l was significantly lower among the 6 subjects with a common donor (1/6) than...Continue Reading

References

Apr 1, 1991·The Journal of Clinical Investigation·C E MackewiczJ A Levy
Nov 24, 1990·BMJ : British Medical Journal·G W RutherfordL S Doll
Jan 1, 1989·Research in Immunology·C M Walker
Nov 1, 1989·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·J D Fortenberry, M L Shew
Sep 5, 1987·British Medical Journal·F de WolfJ van der Noordaa
Sep 1, 1987·Annals of Internal Medicine·H BismuthJ P Benhamou
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·P RuutuT Ruutu

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Citations

Jan 1, 1995·Genetica·E Papadopulos-EleopulosB A Page
May 1, 1997·The Journal of Infection·A M Lever
Jan 1, 1996·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H HendelJ F Zagury
Oct 1, 1995·Trends in Microbiology·M R Klein, F Miedema
Sep 21, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M R BirchJ S Sullivan
Feb 26, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Katherine KedzierskaSuzanne M Crowe
Jun 1, 1993·Bio/technology·E Papadopulos-EleopulosJ M Papadimitriou
Jun 3, 1999·The New England Journal of Medicine·K L Collins, G J Nabel
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ann DuerrLawrence Corey
May 3, 2000·AIDS Research and Human Retroviruses·L A Obert, E A Hoover
Mar 1, 1994·AIDS Research and Human Retroviruses·S OkaK Shimada
Jan 1, 1995·AIDS Research and Human Retroviruses·J LearmontJ S Sullivan
Feb 10, 1997·AIDS Research and Human Retroviruses·G L Ada, M J McElrath
Nov 10, 2009·AIDS Research and Human Retroviruses·D B TzitzivacosM A Papathanasopoulos
Mar 29, 2012·The Journal of Infectious Diseases·Sarah BoudováC David Pauza
Jun 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·C J SandyC S Migdal
Dec 15, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H FarzadeganJ B Margolick
Mar 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A PetrucciG Angarano
Jun 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·E A OperskalskiD O Stram
Aug 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S FujiiK Takatsuki
Oct 13, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L M SkinnerM Katzman
Feb 3, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S A BlasdallJ S Sullivan

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