Long-Term Telbivudine Treatment Results in Resolution of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis B

Advances in Therapy
Jin-Lin HouNikolai V Naoumov

Abstract

The long-term goal of chronic hepatitis B (CHB) treatment is improvement of liver disease and prevention of cirrhosis. The aim of this study was to assess whether prolonged telbivudine treatment improves liver inflammation and fibrosis. The primary objective was to evaluate the proportion of patients with absence/minimal inflammation (Knodell necroinflammatory score ≤3) on liver biopsy at Year 5. Fifty-seven patients aged 16-70 years with a clinical history of CHB and active viral replication (38 hepatitis B e antigen [HBeAg] positive and 19 HBeAg negative) were followed for 6 years: 33 received telbivudine 600 mg/day continuously for 5 years; 24 received lamivudine 100 mg/day for 2 years and then telbivudine for 3 years. Liver biopsies were taken pre-treatment and after 5 years of treatment. At baseline, mean (standard deviation) serum hepatitis B virus (HBV) DNA load was 8.5 (1.7) log10 copies/mL, Knodell necroinflammatory score was 7.6 (2.9), and Ishak fibrosis score was 2.2 (1.1). After antiviral treatment (median duration: 261 weeks), liver histology improved with increased proportions of patients with absence/minimal liver inflammation (Knodell necroinflammatory score ≤3), from 16% (9/57) at baseline to 98% (56/57), and a...Continue Reading

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Citations

Jun 23, 2020·Chinese Medical Journal·Ya-Meng SunHong You
Mar 19, 2020·Journal of Gastroenterology·Raquel Scherer de FragaSuzane Kioko Ono
Oct 4, 2021·Population Health Metrics·Shih-Yung SuWen-Chung Lee

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Methods Mentioned

BETA
biopsies
biopsy
PCR

Clinical Trials Mentioned

NCT00877149
NCT00057265
NCT00131742
NCT00142298
NCT00646503

Software Mentioned

FibroScan

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