Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity

The Journal of Clinical Endocrinology and Metabolism
Tinna TraustadottirT W Storer

Abstract

Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity, or peak oxygen uptake (V̇O2peak), in healthy older men with low testosterone have not been evaluated. To determine the effects of testosterone supplementation on V̇O2peak during incremental cycle ergometry. A double-blind, randomized, placebo-controlled, parallel-group trial (Testosterone's Effects on Atherosclerosis Progression in Aging Men). Exercise physiology laboratory. Healthy men aged ≥ 60 years with total testosterone levels of 100 to 400 ng/dL (3.5 to 13.9 nmol/L) or free testosterone levels < 50 pg/mL (174 pmol/L). Randomization to 1% transdermal testosterone gel adjusted to achieve serum levels of 500 to 950 ng/dL or placebo applied daily for 3 years. Change in V̇O2peak. Mean (±SD) baseline V̇O2peak was 24.2 ± 5.2 and 23.6 ± 5.6 mL/kg/min for testosterone and placebo, respectively. V̇O2peak did not change in men treated with testosterone but fell significantly in men receiving placebo (average 3-year decrease, 0.88 mL/kg/min; 95% CI, -1.39 to 0.38 mL/kg/min; P = 0.035); the difference in change in V̇O2peak between groups was significant (average 3-year difference, 0.91 mL/kg/min; 95% CI...Continue Reading

Associated Clinical Trials

Oct 18, 2005·Shalender Bhasin, Shalender Bhasin

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Citations

Jan 12, 2019·International Journal of Sport Nutrition and Exercise Metabolism·Ben DesbrowKirsty J Elliott-Sale
May 24, 2019·Expert Opinion on Pharmacotherapy·Justin P Hardee, Gordon S Lynch
Dec 6, 2019·Scientific Reports·Alessandra Pucci Mantelli GalhardoEdmund Chada Baracat
May 28, 2019·Nature Reviews. Cardiology·Thiago Gagliano-Jucá, Shehzad Basaria
Jun 28, 2019·Frontiers in Endocrinology·Du Soon Swee, Earn H Gan
Dec 23, 2020·The Journal of Clinical Endocrinology and Metabolism·Yoann BarnouinDennis T Villareal
Nov 21, 2020·Annual Review of Medicine·Marcelo Rodrigues Dos Santos, Shalender Bhasin
Jun 23, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zelal Jaber KharabaYassen Alfoteih
Mar 20, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Lauren C ChaslandDaniel J Green
Aug 15, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shalender Bhasin, Noelle Ozimek

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