Long-term thalidomide for actinic prurigo

The Australasian Journal of Dermatology
S A Yong-Gee, J B Muir

Abstract

A 35-year-old man presented at the age of 8 years with recurrent pruritic papulovesicular lesions on his face and body appearing within minutes of light exposure. A recent positive finding of human leukocyte antigen (HLA) DR4 with the rare DRB1*0407 subtype confirmed a diagnosis of actinic prurigo. Thalidomide (100 mg/day) was commenced at the age of 11 years after an unsuccessful trial of other treatments and his lesions resolved within 2 months. Attempts to withdraw thalidomide have resulted in recurrence of photosensitivity and the patient has remained on a virtually continuous maintenance dose of thalidomide (50 mg/ day) for 23 years. His cumulative dose is estimated to be over 400 g. To date, he has not experienced any adverse effects and investigations have shown no evidence of neuropathy. This case illustrates the safe long-term use of thalidomide.

References

Apr 1, 1985·The British Journal of Dermatology·C H WulffH Brodthagen
Dec 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·P M Fullerton, D J O'Sullivan
Sep 1, 1973·International Journal of Dermatology·F Londoño
Apr 1, 1983·The British Journal of Dermatology·C R LovellI A Magnus
Jan 1, 1995·European Journal of Clinical Pharmacology·C C HarlandJ R Marsden
Dec 1, 1996·Journal of the American Academy of Dermatology·S TsengJ L Shupack
May 8, 1999·The British Journal of Dermatology·S A GrabczynskaJ L Hawk

❮ Previous
Next ❯

Citations

Nov 9, 2002·The Australasian Journal of Dermatology·Rohan B CrouchChristopher S Baker
Nov 9, 2002·The Australasian Journal of Dermatology·Nina Y WinesMichael P Wines
May 2, 2002·The Australasian Journal of Dermatology·Rohan CrouchChristopher Baker
Mar 5, 2010·Pediatric Dermatology·Gene KitamuraLinda Golkar
Nov 2, 2013·Indian Journal of Dermatology, Venereology and Leprology·Khor Jia KerColin Thiam Seng Theng
Jun 4, 2014·Dermatologic Clinics·Martha C ValbuenaHenry W Lim
Dec 1, 2004·International Journal of Dermatology·Iris Estrada-GLuciano Domínguez-Soto
Sep 25, 2008·Photodermatology, Photoimmunology & Photomedicine·Gayle RossChris Baker
Dec 15, 2010·Anais Brasileiros De Dermatologia·Patricia Erica Christofoletti DaldonMariane Correa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Australasian Journal of Dermatology
J C NgChristopher S Baker
The British Journal of Dermatology
M L BatardP Thomas
Photodermatology, Photoimmunology & Photomedicine
Rutsanee AkaraphanthPimonpun Gritiyarangsan
© 2022 Meta ULC. All rights reserved