PMID: 2483446Jan 1, 1989Paper

Long-term therapy of chronic congestive heart failure with ibopamine: a multicenter trial.

Journal of Cardiovascular Pharmacology
E RolandiV Cicchetti

Abstract

The present multicenter open investigation was designed to provide information on the adverse reaction rate, drug interaction, and survival in a group of 544 cardiac patients treated for 1 year with ibopamine either alone or in association with digitalis, diuretics, and other drugs. Some efficacy parameters were also considered. Heart failure was due to idiopathic dilated cardiomyopathy (21%), ischemic heart disease (32%), hypertensive heart disease (31%), and others (16%). Ibopamine was given alone to 39 patients; the others were given the drug in association with digitalis, diuretics, and vasodilators. One hundred forty patients did not complete the trial (25.7%). The most common causes of discontinuation were death (12.5%), noncompliance with the protocol (5%), and adverse events (3.9%). The clinical conditions and NYHA functional class improved in most patients. The cardiothoracic ratio decreased on average. The 1-year mortality rates associated with NYHA class II, III, and IV were 4.4, 13.8, and 37.2%, respectively. Survival tended to be shorter in a small group of 22 patients with hyponatremia, thus confirming some previous reports. Adverse experiences were mainly related to cardiovascular and gastrointestinal systems; th...Continue Reading

Citations

Mar 1, 1995·Clinical Cardiology·M Metra, L Dei Cas
Apr 1, 1996·Aging : Clinical and Experimental Research·P U Carbonin, G Zuccalà
Jun 4, 1992·The American Journal of Cardiology·C V Leier

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