Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study

Diabetes/metabolism Research and Reviews
D R MatthewsG Schernthaner

Abstract

This 52-week, randomized, double-blind study compared the efficacy and safety of metformin plus pioglitazone with the established combination of metformin plus gliclazide in type 2 diabetes mellitus. Patients with poorly controlled type 2 diabetes (HbA1c > or = 7.5% to < or =11.0%) received either pioglitazone 15 mg o.d. (titrated up to 45 mg; n = 317) or gliclazide 80 mg o.d. (titrated up to 320 mg; n = 313) and metformin at the pre-study dose. HbA1c, fasting plasma glucose (FPG), insulin, lipids and the urinary albumin/creatinine ratio were measured. There were no significant differences in HbA1c (1% decrease in both groups) and FPG between groups. There was a decrease in fasting insulin in the pioglitazone group compared to an increase in the gliclazide group (p < 0.001). There were significantly greater improvements in triglycerides and HDL-cholesterol in the metformin plus pioglitazone group compared to the metformin plus gliclazide group (p < 0.001). Mean LDL-cholesterol decreased with metformin plus gliclazide and increased with metformin plus pioglitazone (p < 0.001); however, this increase was considerably less marked than that in HDL-cholesterol. The mean urinary albumin/creatinine ratio was reduced by 10% in the metf...Continue Reading

References

Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Jul 16, 1996·Biochemical and Biophysical Research Communications·A ElbrechtJ Berger
Aug 24, 1999·Annals of Internal Medicine·R A DeFronzo
Mar 13, 2001·The American Journal of Cardiology·E Stein
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·G CharpentierS Halimi
Mar 29, 2002·Diabetes/metabolism Research and Reviews·Shaoming Song
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Yoshinori MiyazakiRalph A DeFronzo
Sep 3, 2002·Journal of the American College of Cardiology·Steven P Marso
Sep 27, 2002·Diabetes/metabolism Research and Reviews·Guillaume Charpentier

❮ Previous
Next ❯

Citations

May 29, 2008·Diabetes, Obesity & Metabolism·E MannucciN Marchionni
Apr 28, 2005·International Journal of Clinical Practice·J William Lester, A W Fernandes
Nov 1, 2006·International Journal of Clinical Practice·A Barnett
May 22, 2007·International Journal of Clinical Practice·R Donnelly
Jun 6, 2009·International Journal of Clinical Practice·G Schernthaner
Aug 19, 2008·BMC Medical Research Methodology·Jianbing MaWeiya Zhang
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Giuseppe Derosa, Sibilla At Salvadeo
May 14, 2009·Vascular Health and Risk Management·Anthony H Barnett
Sep 23, 2010·Vascular Health and Risk Management·Curtis TriplittRalph A DeFronzo
Sep 18, 2014·Current Treatment Options in Oncology·Albert AttiaMichael Chan
Jun 7, 2011·Expert Opinion on Pharmacotherapy·Thomas ForstAndreas Pfützner
Mar 20, 2010·Current Medical Research and Opinion·Angel RodríguezJesús Reviriego
Aug 23, 2005·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·Gerit-Holger Schernthaner, Guntram Schernthaner
Jun 15, 2007·Current Medical Research and Opinion·Anthony BarnettRachel Mann
Aug 3, 2006·Kidney International·P A Sarafidis, G L Bakris
Mar 1, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D Bolignano, C Zoccali
Jul 14, 2010·Cardiology Clinics·Sandeep A Saha, Katherine R Tuttle
Jan 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pantelis A SarafidisAnastasios N Lasaridis
Dec 28, 2007·Diabetes Research and Clinical Practice·Jochen Seufert, Richard Urquhart
Oct 9, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M ComaschiUNKNOWN COM06 Study Investigators
Oct 13, 2007·Diabetes Research and Clinical Practice·Matteo MonamiEdoardo Mannucci
Jul 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·G Belcher, G Schernthaner
Jul 21, 2009·Diabetes, Obesity & Metabolism·G CharpentierUNKNOWN F-PIO-100 Study Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.