PMID: 9661803Jul 14, 1998Paper

Long-term therapy with an ACE inhibitor, temocapril, reduces microalbuminuria in essential hypertension

Hypertension Research : Official Journal of the Japanese Society of Hypertension
H ShionoiriG Yasuda

Abstract

The present study was conducted to prospectively evaluate whether a new ACE inhibitor, temocapril, could modify urinary microalbumin excretion rate (UAE) in a group of hypertensive outpatients who had no evidence of renal impairment. Sixty-three outpatients (32 men and 31 women; mean age, 59.9 +/- 1.5 yr) with essential hypertension entered the study, all having been treated for at least 6 mo with dihydropyridine calcium-channel blockers (CCBs: nitrendipine, nisoldipine, or amlodipine). Their blood pressures (BPs) had been controlled to adequate levels with the CCBs. None had overt proteinuria (determined by Albustix) or abnormal serum creatinine levels. After 3 mo of baseline observation under the previous treatment, the subjects were randomly divided into two groups. In group A (n = 31), the previously used CCBs were switched to temocapril, 2 to 4 mg once daily for 12 mo, and BP was controlled at a level equivalent to that during CCB treatment. In group B (n = 32), the subjects were maintained on their previous treatment for a further 12 mo. The effect of temocapril on BP appeared to be clinically similar to that of the previously used CCBs, but it significantly decreased UAE as compared with the previous therapy. In group A,...Continue Reading

Citations

Aug 30, 2001·American Heart Journal·J D KayS R Daniels
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshio HoritaShigeru Kohno
Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshihiko KannoHiromichi Suzuki
Jun 6, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sei TsunodaShuichi Takishita

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