PMID: 11321193Apr 26, 2001Paper

Long-term therapy with glatiramer acetate in multiple sclerosis: effect on T-cells

Multiple Sclerosis : Clinical and Laboratory Research
S RaghebR P Lisak

Abstract

Glatiramer acetate (GA) is an immunotherapeutic drug for multiple sclerosis (MS). Several mechanisms of action have been demonstrated which target and affect T-cells that are specific for myelin antigen epitopes. We measured the in vitro proliferation of GA-responsive T-cells from untreated MS patients and from normal healthy subjects; in addition, we determined the effect of prolonged GA therapy or interferon-beta therapy on the in vitro proliferation of GA-responsive T-cells of MS patients. We found that GA induces the proliferation of T-cells isolated from individuals who have not been previously exposed to GA, and that long-term in vivo therapy of MS patients with GA abrogates the GA-induced proliferative response of T-cells. In GA-treated patients, there is no evidence of generalized immunosuppression; both tetanus toxoid and anti-CD3 induced proliferative responses remain unaffected. We propose that prolonged in vivo exposure to GA may result in the eventual induction of anergy or deletion of a population of GA-responsive cells that may also be T-cells that are pathogenic in MS. This mechanism of action, in addition to other mechanisms that have been demonstrated, suggests that GA has pleiotropic effects on the immune sys...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumM Sela
Aug 1, 1991·Neuropathology and Applied Neurobiology·C S Raine
Dec 1, 1985·Neurology·C F BrosnanB R Bloom
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumM Sela
Aug 1, 1971·European Journal of Immunology·D TeitelbaumM Sela
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·R AharoniR Arnon
Apr 29, 1998·Immunology and Cell Biology·C Ewing, C C Bernard

❮ Previous
Next ❯

Citations

Nov 19, 2004·Journal of Neurology·Hans-Peter HartungYannis Zoukos
Oct 22, 2003·Journal of the Neurological Sciences·Man ChenSuhayl Dhib-Jalbut
May 3, 2003·Pharmacology & Therapeutics·Suhayl Dhib-Jalbut
Apr 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M SchmiedD A Hafler
Oct 19, 2013·Journal of Neuroinflammation·Madhan ThamilarasanUwe Klaus Zettl
Apr 1, 2007·Neuropsychiatric Disease and Treatment·Alex TselisRobert P Lisak
Jun 9, 2005·Expert Review of Neurotherapeutics·Brenda Banwell
Apr 20, 2010·Expert Opinion on Drug Metabolism & Toxicology·Kenneth P Johnson
Sep 18, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rosario BillettaSalvatore Albani
Jul 24, 2007·Autoimmunity Reviews·Wiebke Schrempf, Tjalf Ziemssen
Jan 1, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D S Kasatkin
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R M ValenzuelaS Dhib-Jalbut
Jul 8, 2017·Brain Sciences·Narges DargahiVasso Apostolopoulos
Jul 10, 2008·Multiple Sclerosis : Clinical and Laboratory Research·A L K HestvikT Holmoy
Oct 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Christian BarroJens Kuhle
Mar 28, 2012·Expert Review of Neurotherapeutics·Kenneth P Johnson
Oct 1, 2010·Continuum : Lifelong Learning in Neurology·Amer M Awad, Olaf Stüve
May 14, 2005·Current Opinion in Neurology·Xavier Montalban
Jun 13, 2006·Multiple Sclerosis : Clinical and Laboratory Research·C C FordUNKNOWN Copaxone Study Group
Feb 28, 2009·Expert Opinion on Pharmacotherapy·Haim VarkonyRivka Schwartz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.