Long-term tolerance of preservative-free eye drops containing macrogol hydroxystearate as an excipient

Journal français d'ophtalmologie
K Viaud-QuentricP P Elena

Abstract

This in vivo animal study was conducted to assess the tolerability of macrogloglycerol hydrostearate 40 (MGH 40), commonly used as a solubilizing excipient in prostaglandin F2α analogue eye drops without benzalkonium chloride. Twenty-eight (14 males and 14 females) New Zealand white albino rabbits in good health and with no signs of ocular irritation were randomly assigned to receive 25 μL instillations of a solution containing 10% MGH 40 in the right eye 3 times daily for either 3 or 6 months. Ocular examinations of the conjunctiva, cornea and iris (using an ophthalmoscope and slit-lamp), corneal sensitivity, and intraocular pressure were assessed in both the right (treated) and left (untreated) eyes throughout the study. General characteristics, hematology and serum biochemistry parameters were also assessed throughout the study and necropsy examinations were performed at study completion. There were no treatment-related effects on the cornea, conjunctiva, iris, or intraocular pressure. Transient findings were generally seen in the untreated as well as the treated eye. Similarly, there were no treatment-related findings in either the hematology or serum biochemistry data or at necropsy. There were no differences based on gend...Continue Reading

References

Jul 1, 1972·Experimental Eye Research·Y Kikkawa
Aug 1, 1997·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·R G CohenM Lahav
Aug 13, 2002·The Veterinary Clinics of North America. Exotic Animal Practice·Stacy E Andrew
Mar 23, 2010·Progress in Retinal and Eye Research·Christophe BaudouinFrançoise Brignole-Baudouin
Nov 15, 2012·Investigative Ophthalmology & Visual Science·Aude PaulyChristophe Baudouin

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