Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats

Journal of Toxicology and Environmental Health. Part a
J M CyphertStephen H Gavett

Abstract

Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dorado tremolite (ED), and Ontario ferroactinolite cleavage fragments (ON) were compared in male Fischer 344 (F344) rats 15 mo after exposure. Rat-respirable fractions of LA and SM displayed greater mean lengths and aspect ratios than ED and ON. After a single intratracheal (IT) instillation (0.5 or 1.5 mg/rat), persistent changes in ventilatory parameters and a significant increase in lung resistance at baseline and after methacholine aerosol dosing were found only in rats exposed to 1.5 mg SM. High-dose ED significantly elevated bronchoalveolar lavage lactate dehydrogenase (LDH) activity and protein levels, while high-dose SM increased γ-glutamyl transferase and LDH activities. A moderate degree of lung interstitial fibrosis after exposure to 1.5 mg SM persisted 15 mo after exposure, unchanged from previous findings at 3 mo. LA induced mild fibrosis, while ED and ON produced minimal and no apparent fibrosis, respectively. Bronchioloalveol...Continue Reading

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Citations

Jul 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michele CarboneShakun Malik
Aug 26, 2016·Journal of Toxicology and Environmental Health. Part a·Mariana T FarcasAnna A Shvedova
Oct 6, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pascal AndujarDidier Jean
Mar 29, 2018·Journal of Toxicology and Environmental Health. Part a·Min-Seok KimKyuhong Lee
Sep 20, 2018·Journal of Toxicology and Environmental Health. Part a·Jean C PfauMarvin J Fritzler
May 6, 2019·Environmental Science and Pollution Research International·Yan CuiQingbi Zhang
Dec 28, 2017·Journal of Toxicology and Environmental Health. Part a·Naveena YanamalaAnna A Shvedova
Jul 8, 2020·Environmental Science and Pollution Research International·Erika P DonadoLuis F O Silva
Feb 4, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·Linda D DellKenneth A Mundt
Nov 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amjad Ali KhanArshad Husain Rahmani

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Methods Mentioned

BETA
x-ray
bronchoalveolar
Protein Assay
light microscopy

Software Mentioned

GraphPad
Prism

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