Long-term treatment of erectile dysfunction with a phosphodiesterase-5 inhibitor and dose optimization based on nocturnal penile tumescence

BJU International
Michael J MathersFrank Sommer

Abstract

To test the hypothesis that a variable dosage of the oral phosphodiesterase type 5 (PDE5) inhibitor sildenafil (25, 50, 100 mg) or vardenafil (5, 10, 25 mg) determined according to results obtained from nocturnal penile tumescence and rigidity (NPTR, RigiScan), given nightly for 1 year, can improve spontaneous erectile function (EF) in men with mild-to-moderate arteriogenic erectile dysfunction (ED); this regimen was compared with a fixed daily dosage of sildenafil 25 mg or vardenafil 5 mg. In a prospective open-label, parallel-group trial 154 men with ED were randomized either to fixed low-dose sildenafil 25 mg or vardenafil 5 mg (group 1) or to the lowest erectile dosage of sildenafil (25, 50 or 100 mg) or vardenafil (5, 10 or 20 mg) (group 2) provoking an erectile event as measured by NPTR nightly for 1 year. The EF domain of the International Index of Erectile Function (IIEF) was assessed before and 1 year after the beginning of treatment, and at 4 weeks after ending treatment. After 1 year, 27 of 63 (64%) evaluable men in group 1 had an EF domain score in the normal range, vs 46 of 61 (75%) men in group 2. After the subsequent 4-week wash-out phase, both groups continued to have improved EF domain scores; 22 of 63 (35%) me...Continue Reading

References

Jan 1, 1972·Journal of Gerontology·I KaracanR L Williams
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Oct 25, 2000·International Journal of Impotence Research·E ChristiansenUNKNOWN Sildenafil Multicentre Study Group
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Jan 1, 1965·Archives of General Psychiatry·C FISHERJ ZUCH
Sep 15, 2005·Clinical Cornerstone·Aly Rashid

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Citations

Jul 18, 2009·International Journal of Impotence Research·C A PalmeriniG Arienti
Jul 25, 2009·International Journal of Clinical Practice·R SadovskyS Sorsaburu
Aug 28, 2012·Urology·Valter JavaroniMario Fritsch Neves
Apr 23, 2009·Orvosi hetilap·Péter RieszImre Romics

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