Long-term treatment of essential hypertension using nadolol and hydrochlorothiazide combined

British Journal of Clinical Pharmacology
M M el-MehairyS S Tadros

Abstract

1 The stepped care approach for the treatment of hypertension was adopted in a study at Ain Shams Hospital using hydrochlorothiazide (HCT) and a new beta-blocker, nadolol. Sixty mild to moderately hypertensive patients were studied for 20 weeks (2 weeks no antihypertendive the therapy, 3 weeks placebo, 3 weeks HCT, 4 weeks nadolol + HCT dose titration and 8 weeks nadolol + HCT maintenance). The dose of HCT was 50 mg once daily throughout the study except for six patients who had their HCT dose increased to 100 mg daily during maintenance. The dose of nadolol ranged from 40-240 mg daily. 2 No patient on HCT monotherapy achieved full control of his supine diastolic blood pressure (SDBP less than 90 mm Hg). On combined therapy, 55 patients (91.7%) showed a full response, whereas the remaining five patients a good or adequate response. 3 Thirty-two of these patients agreed to continue in the study for a further 21 months (totalling 2 yr of therapy). To date, 15 of them have completed a total of 10 months, 7 have completed 11 months and 10 have completed 12 months. The delta percentage decrease in supine BP continued to be 28.0 and 19.5 for systolic and diastolic BPs respectively. 4 No significant changes in funduscopies, chest X-ra...Continue Reading

References

Sep 17, 1981·The New England Journal of Medicine·W H Frishman
Jan 1, 1983·European Journal of Clinical Pharmacology·A RouxB Flouvat
Feb 1, 1983·Journal of Clinical Pharmacology·I S CohenS M Hargus
Jan 1, 1982·The Journal of International Medical Research·D González
Jan 1, 1982·The Journal of International Medical Research·M M el-MehairyS S Tadros

Citations

May 1, 1977·Journal of Clinical Pharmacology·J DreyfussD A Willard
Jan 7, 1978·Lancet·G BerglundJ Wikstrand
Jan 23, 1978·JAMA : the Journal of the American Medical Association·E D Frohlich
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Related Concepts

Mercury
Study
Diastolic Blood Pressure
Polychemotherapy
Essential Hypertension
Propanolamines
Drug Evaluation
Hypertensive Disease
Chest X-ray
Blood Pressure

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