PMID: 7541599Jan 1, 1995Paper

Long-term treatment of mood disorders in schizophrenia

Acta Psychiatrica Scandinavica. Supplementum
J M Azorin

Abstract

Mood disorders in schizophrenia are common and are associated with a poor outcome, an increased risk of relapse and a high rate of suicide. Consequently, treatment strategies need to take mood disorders into account. In depressed and actively psychotic schizophrenic and schizoaffective patients, treatment with neuroleptic plus antidepressant may be less effective than neuroleptic alone. However, patients with post-psychotic depression on maintenance neuroleptics respond well to tricyclic antidepressants. Mood disorders can be caused by neuroleptics and if so will often improve if the dose is reduced or if the drug is changed. Anticholinergics may also help. In schizoaffective disorder, lithium is usually beneficial, especially for patients with classical affective disorder. Carbamazepine may be more effective in patients with schizoaffective and schizophreniform disorders. At doses comparable with those effective in schizophrenia, clozapine may be as good or better than conventional neuroleptics in schizophrenic patients with psychotic mood disorder or schizoaffective disorder. In patients with high BPRS anxiety/depression scores, risperidone (8 mg/day) was more effective than haloperidol (10 mg/day). Risperidone at a mean dose...Continue Reading

References

Jan 11, 1991·Archives of General Psychiatry·W T CarpenterA Breier
Sep 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·N Argyle
Oct 1, 1989·Archives of General Psychiatry·M S KramerI Kimes
Jan 1, 1989·Psychopharmacology·D E Casey
Jun 1, 1987·Archives of General Psychiatry·S G SirisT B Cooper
Dec 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·R E DrakeP G Cotton
Jul 1, 1980·The American Journal of Psychiatry·M I Herz, C Melville
Nov 1, 1981·The Journal of Nervous and Mental Disease·W GlazerD Williams
Jun 1, 1994·The American Journal of Psychiatry·S R Marder, R C Meibach
Feb 1, 1994·Archives of General Psychiatry·S G SirisM A Shuwall

❮ Previous
Next ❯

Citations

Apr 20, 2000·British Journal of Clinical Pharmacology·G ApseloffN Gerber
Apr 20, 2000·British Journal of Clinical Pharmacology·J J MiceliA Laurent
Jan 1, 1998·International Journal of Psychiatry in Clinical Practice·D ZullinoP Baumann
Nov 26, 1999·European Psychiatry : the Journal of the Association of European Psychiatrists·H RittmannsbergerH Hinterhuber
Sep 29, 2001·Clinical Neuropharmacology·C Miodownik, V Lerner
Jul 20, 2002·Current Psychiatry Reports·Christian G Kohler, Elise A Lallart
Jul 13, 2001·Journal of Psychopharmacology·S G Siris
Jan 7, 2000·The Psychiatric Clinics of North America·P L ForsterM A Phelps

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here