PMID: 3767276Jul 1, 1986Paper

Long-term trends in biochemical data obtained from two population surveys

Annals of Clinical Biochemistry
P M BroughtonD Ashby

Abstract

A study has been made of the variations in monthly mean values of 10 serum constituents in subjects participating in two partly-concurrent long-term epidemiological surveys. Closely similar patterns of variation were found in men in both surveys and in men and women in one survey. During the 6 years of the study, four types of variation of the monthly mean concentrations were identified in varying combinations: abrupt changes of less than 2% not detected by quality control procedures; a gradual drift in mean value; haphazard variations in mean values; and seasonal variations in bilirubin and urea, identical in men and women. The implications of these findings for the design of long-term epidemiological surveys, and the criteria for designating variations as seasonal, are discussed.

References

Apr 1, 1977·The American Journal of Clinical Nutrition·M W PorterM A Flynn
Jul 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·F V FlynnM J Healy
Nov 1, 1985·Annals of Clinical Biochemistry·P M Broughton, B M Buckley
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Citations

Feb 1, 1989·Journal of Clinical Pathology·S J PocockP M Broughton
Jan 1, 1990·Journal of Clinical Epidemiology·S G Thompson, S J Pocock
Oct 5, 2013·BMC Endocrine Disorders·Maya TanakaRyoichi Takayanagi
May 28, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·L ClarkM Leblanc
Apr 1, 1992·Physical Review. B, Condensed Matter·J N ReimersM Björgvinsson
Oct 4, 2006·Alimentary Pharmacology & Therapeutics·S D ZuckerK E Sherman
Mar 31, 1990·BMJ : British Medical Journal·J Wilton
Jan 1, 1987·Annals of Clinical Biochemistry·P M Broughton, R Holder

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