Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features - The Dialong hand study

PloS One
Karin MagnussonTore Julsrud Berg

Abstract

To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness. In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA1c: 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA1c were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63.0 [7.0], mean [SD] HbA1c: 5.41 [0.32], N = 29 [42%] men). The groups were compared for radiographic hand OA (Kellgren-Lawrence grade ≥2 in ≥1 joint) and erosive hand OA (central erosions in ≥1 joint), Australian/Canadian index (AUSCAN) for hand pain, disability and stiffness using regression analyses adjusted for age, sex, educational level and waist circumference. We found no associations between having long term type 1 diabetes and more prevalent radiographic hand OA (OR = 0.83, 95% CI = 0.38-1.81). We found a trend towards higher prevalence of erosive hand OA in diabetes patients (OR = 2.96, 95% CI = 0.82-10.64). Strong and consistent associations were observed between long term type 1 diabetes and increased hand pain (B = 2.78, 95% CI = 1.6...Continue Reading

References

Feb 1, 1981·Clinical Biochemistry·T M JamesJ H Ladenson
Nov 11, 1999·Twin Research : the Official Journal of the International Society for Twin Studies·U M KujalaM Koskenvuo
Feb 12, 2000·Diabetes Research and Clinical Practice·B S GalerM P Jensen
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Dec 14, 2004·Arthritis and Rheumatism·David T FelsonDavid J Hunter
May 18, 2005·Osteoarthritis and Cartilage·B Slatkowsky-ChristensenN Bellamy
Feb 23, 2007·Annals of the Rheumatic Diseases·S DahaghinH A P Pols
Feb 27, 2007·Osteoarthritis and Cartilage·R D Altman, G E Gold
Jun 3, 2009·Annals of the Rheumatic Diseases·Erlangga YusufMargreet Kloppenburg
Apr 9, 2011·Annals of the Rheumatic Diseases·Francis Berenbaum
Jul 20, 2012·Arthritis Research & Therapy·Erlangga Yusuf
Oct 9, 2012·Osteoarthritis and Cartilage·D T Felson
Nov 8, 2012·Scandinavian Journal of Rheumatology·S Bañón, D A Isenberg
Dec 1, 2012·Osteoarthritis and Cartilage·F Berenbaum

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

AUSCAN

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