Long-term use and tapered dose reduction of intranasal desmopressin in the treatment of enuretic children

British Journal of Urology
M RiccabonaP Glauninger

Abstract

To determine the time taken to achieve complete dryness, the management of desmopressin dosage to reduce the relapse rate, the mean dosage in those responding and any side effects of long-term treatment. Enuretic children (155, 68% boys and 32% girls, mean age 8 years, range 5-19) were treated with desmopressin and assessed. Treatment (intranasal spray) was started with 20 microg desmopressin and titrated to 40 microg (maximum 50 microg) after 2 days if the child did not become dry within 48 h. The maximum dosage was maintained for at least 4-6 weeks. After 4 weeks of complete dryness, the dosage was reduced by 10 microg initially, and after each additional 4 dry weeks, by a further 10 microg; medication was stopped only after 4 dry weeks at 10 microg. Of the children, 85% responded to intranasal desmopressin therapy; 71% achieved complete dryness with no relapses, remaining dry with no further treatment, 7% achieved dryness after relapses during or after therapy, 7% improved (no more than two wet nights per week) and 15% did not respond to therapy or improved only slightly (> 2 wet nights per week). The mean duration of therapy was 28 weeks, the mean dose of desmopressin was 30 microg and the median follow-up 18 months. There ...Continue Reading

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Citations

Oct 3, 2002·Indian Journal of Pediatrics·S Aneja
Jun 25, 2010·Der Urologe. Ausg. A·M Riccabona
Dec 18, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cherry Fai-Ngo NgUNKNOWN Hong Kong Childhood Enuresis Study Group
Jun 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A TriantafyllidisS Touloupidis
Oct 9, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·E J Mikkelsen
Nov 10, 2004·Clinical Psychology Review·Richard J Butler
Aug 22, 2009·The Journal of Urology·Daniela Marschall-KehrelUNKNOWN Enuresis Algorithm of Marschall Survey Group
Sep 1, 2006·Expert Review of Endocrinology & Metabolism·Ormella CuomoRoberto Del Gado
Oct 14, 2006·Current Opinion in Urology·S Agarwal
Jun 22, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Hirokazu IkedaKeiichi Isoyama
Jun 19, 2004·Scandinavian Journal of Urology and Nephrology·Richard J ButlerDianne Doherty-Williams
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·R J Butler, P Holland

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