Long-term use of antiplatelet drugs by stroke patients: a follow-up study based on prescription register data.

European Journal of Clinical Pharmacology
Kamilla ØstergaardDavid Gaist

Abstract

Treatment with antiplatelet drugs is a key element of secondary stroke prevention. We investigated long-term antiplatelet drug use in stroke patients with a focus on non-persistence. Population-based prescription register data were used to determine antiplatelet drug use in a cohort of stroke patients discharged from a Danish neurology department. The antiplatelet drugs comprised acetylsalicylic acid (ASA), clopidogrel and dipyridamole (if combined with ASA use). Non-persistence was defined as failure to present a prescription for antiplatelet drugs within 180 days after the dosage of a previous prescription had run out, or within 180 days after discharge. Cox regression was used to identify risk factors for non-persistence. The cohort comprised 503 patients with ischaemic stroke discharged in 1999-2001. During follow-up (median 2.8 years, interquartile range 0.8-7.8 years), 486 of the subjects presented prescriptions for antiplatelets. Most subjects used a dual regimen of ASA and dipyridamole (N = 320). Of 110 non-persistent subjects in this group, 64 stopped using ASA, but continued to use dipyridamole in monotherapy. Overall, 181 patients (36 %) were non-persistent. Stroke severity was inversely associated with the risk of n...Continue Reading

References

Jun 1, 1989·Archives of Neurology·L B GoldsteinJ N Davis
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·T SappokH C Koennecke
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Søren BakDavid Gaist
Apr 11, 2003·Cerebrovascular Diseases·Gerhard F HamannUNKNOWN German Stroke Data Bank
Mar 4, 2006·Pharmacoepidemiology and Drug Safety·Susan E AndradeK Arnold Chan
Dec 17, 2008·Pharmacoepidemiology and Drug Safety·Lars Hougaard NielsenNiels Keiding
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Eva-Lotta GladerMichael Lundberg
Sep 9, 2011·Neurology·C D BushnellUNKNOWN AVAIL Investigators

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Citations

Nov 20, 2013·European Journal of Clinical Pharmacology·Kamilla ØstergaardDavid Gaist
May 25, 2013·Pharmacoepidemiology and Drug Safety·Anton Pottegård, Jesper Hallas
Apr 19, 2015·BMC Medical Informatics and Decision Making·Antti TanskanenJari Tiihonen
Jun 29, 2018·Pharmacoepidemiology and Drug Safety·Lotte RasmussenAnton Pottegård
Apr 24, 2020·Neurological Research·Dong Eun Jang, Julie Ann Zuñiga
Mar 12, 2017·Aging Clinical and Experimental Research·Martin WawruchRashmi Shah

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