Abstract
Hepatitis B virus (HBV) infection is still prevalent in Asia, including Thailand. HBV can archive in hepatocytes for life and can reactivate after immunosuppression and chemotherapy administration. Use of immunosuppressive agents is recommended in many rheumatologic diseases and reactivation of HBV can occur. Data regarding the effect of methotrexate (MTX) on HBV reactivation is scanty. MTX is a well known cause of hepatic fibrosis but its effect on HBV reactivation is not clearly understood. There is no specific recommendation for HBV prophylaxis for patients using MTX. This study aimed to determine the prevalence of HBV seromarkers in rheumatologic patients who were treated with long-term MTX and to evaluate the hepatitis outcome in the patients with positive HBV markers. This was a cross-sectional study at the Rheumatology Clinic, Siriraj Hospital, Bangkok, Thailand. Patients aged 15 years or older treated with MTX more than 24 weeks were invited in the study. Review of medical history, MTX prescription and dosage during the last 52 weeks, blood tests for liver function tests, HBV serology, and HBV DNA viral load were performed. The exclusion criteria included patients who were treated with biological DMARDs, drugs active ag...Continue Reading
References
Jan 1, 1991·Gastroenterology·A S LokD Todd
Mar 1, 1990·Annals of Internal Medicine·M A FlowersR D Inman
Mar 7, 2001·Arthritis and Rheumatism·S ItoF Gejyo
Mar 5, 2003·Seminars in Liver Disease·Giovanna Fattovich
Jun 12, 2004·Seminars in Liver Disease·Brian J McMahon
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Jun 9, 2005·Transplantation·Antje KnöllWolfgang Jilg
May 5, 2006·Seminars in Liver Disease·Stephanos J Hadziyannis, George V Papatheodoridis
Jul 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ayse L MindikogluEugene R Schiff
Sep 28, 2006·Tropical Medicine & International Health : TM & IH·Voranush ChongsrisawatYong Poovorawan
Aug 24, 2007·Gut·G FattovichF Donato
Dec 22, 2007·Journal of Hepatology·Giovanna FattovichFrancesco Donato
Jun 3, 2008·Arthritis and Rheumatism·Kenneth G SaagUNKNOWN American College of Rheumatology
Aug 22, 2008·Journal of Hepatology·Giovanni RaimondoFabien Zoulim
Sep 9, 2011·Modern Rheumatology·Keisuke WatanabeYoshiaki Ishigatsubo
Nov 15, 2011·European Journal of Internal Medicine·Massimo MarignaniGianfranco Delle Fave
Citations
Sep 27, 2015·Rheumatology International·Chien-Hsueh TungChing-Chih Lee
Sep 8, 2016·The Lancet Infectious Diseases·Vincent MalletUNKNOWN ECIL-5
Jul 15, 2017·Inflammatory Bowel Diseases·H Matthew CohnEdward V Loftus
Jul 31, 2018·Expert Review of Anti-infective Therapy·Mariantonietta PisaturoNicola Coppola
Sep 12, 2018·The Annals of Pharmacotherapy·Rhiannon M BathKellie J Goodlet
Sep 3, 2018·The Journal of Rheumatology·Stephanie O KeelingNancy Santesso
Oct 7, 2016·The Open Rheumatology Journal·Martin FeuchtenbergerMichael Rupert Kraus
Jun 22, 2019·American Journal of Clinical Dermatology·Stefano PiasericoFrancesco Paolo Russo
Jul 13, 2020·Dermatologic Therapy·Leena ChularojanamontriNorramon Charoenpipatsin
Dec 20, 2019·Expert Review of Clinical Immunology·Ying-Ming Chiu, Der-Yuan Chen
Mar 24, 2016·World Journal of Hepatology·Fernando Bessone, Melisa Dirchwolf
Jul 4, 2018·Clinical Drug Investigation·Sze-Wen TingYu-Huei Huang
Mar 25, 2020·Therapeutic Advances in Musculoskeletal Disease·Christos KoutsianasDimitrios Vassilopoulos
Oct 30, 2019·International Journal of Molecular Sciences·Yosra BedouiPhilippe Gasque
Sep 9, 2016·World Journal of Gastroenterology : WJG·Claudio BonifatiLorenzo Nosotti