Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplasty

Cornea
Jasmeet S DhaliwalStephen C Kaufman

Abstract

To evaluate the long-term efficacy and side effects of off-label topical tacrolimus 0.03% ointment (Protopic; Fujisawa Health, Deerfield, IL) as a sole second-line immunosuppressive agent in the management of high-risk corneal grafts. Four consecutive patients underwent high-risk penetrating keratoplasty (4 grafts) with a prior diagnosis of corneal scar secondary to herpetic keratitis, keratoconus, acanthamoeba keratitis, and Fuchs endothelial dystrophy, respectively. All 4 patients developed steroid-induced glaucoma and failed traditional immunosuppressant therapy. Patients were started on topical tacrolimus ointment 0.03%, twice daily, which was tapered to the lowest possible therapeutic dose that maintained its antirejection efficacy. Patients were monitored for adverse treatment effects. The mean follow-up was 33 months (range, 26-48 months), and the mean treatment duration was 22.6 months (range, 13-32 months). All 4 high-risk corneal transplant patients experienced episodes of acute rejection that was successfully reversed with topical tacrolimus treatment. During tacrolimus treatment, there were no further episodes of graft rejection and no incidents of herpes simplex virus infection or reactivation, with the longest fol...Continue Reading

Associated Clinical Trials

May 10, 2013·Fernando Eiji Sakassegawa Naves

References

Feb 1, 1991·Ophthalmology·S J TuftR J Buckley
Jul 1, 1988·Transplantation·J C Hill, R Maske
Aug 1, 1989·Ophthalmology·M W BelinJ Chmielinska
Mar 1, 1980·The British Journal of Ophthalmology·W F ShepherdB R Jones
May 1, 1982·The British Journal of Ophthalmology·P A HunterB R Jones
May 1, 1982·The British Journal of Ophthalmology·T A BellK G McCullagh
Dec 15, 1994·American Journal of Ophthalmology·M IshiokaS Tanaka
Jun 15, 1993·American Journal of Ophthalmology·M MochizukiG Inaba
Jun 23, 1993·Annals of the New York Academy of Sciences·T E StarzlM Trucco
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·U BenelliM Nardi
Nov 5, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A ReisE Godehardt
Sep 10, 2003·Transplantation Proceedings·M G Crespo-Leiro
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sangeeta M BhoradeEdward R Garrity
Feb 13, 2007·European Journal of Ophthalmology·M S FigueroaL Orte
May 1, 2007·Ophthalmology·Aideen C HoganRichard W J Lee

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Citations

Jul 9, 2010·International Ophthalmology Clinics·Maeve O'Doherty, Conor C Murphy
Sep 7, 2013·The British Journal of Ophthalmology·Otavio A MagalhaesSergio Kwitko
Mar 30, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jiajie ZhaiJiaqi Chen
Apr 4, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eliya LevingerDavid Verssano
Feb 12, 2013·American Journal of Ophthalmology·Young Ji LeeKyoung Yul Seo
Dec 12, 2012·Journal français d'ophtalmologie·A-S GauthierB Delbosc
Apr 16, 2011·Journal français d'ophtalmologie·E GuilbertV Borderie
May 10, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Bernardo Kaplan MoscoviciRichard Yudi Hida
Oct 18, 2014·Seminars in Ophthalmology·Ramez I Haddadin, James Chodosh
Oct 22, 2013·Seminars in Ophthalmology·Yureeda Qazi, Pedram Hamrah
Aug 8, 2012·Korean Journal of Ophthalmology : KJO·Eun Hye RyuTae-Young Chung
Oct 18, 2016·Cornea·Samrat Chatterjee, Deepshikha Agrawal
Jan 1, 2016·Vestnik oftalmologii·S V TrufanovD A Krakhmaleva
Mar 20, 2012·Expert Opinion on Pharmacotherapy·Mohammed ZiaeiBita Manzouri
Sep 19, 2017·Current Eye Research·Fernando Eiji Sakassegawa-NavesRichard Yudi Hida
Sep 30, 2017·Current Ophthalmology Reports·Sayena JabbehdariAli R Djalilian
Mar 14, 2017·Eye and Vision·Samir S Shoughy
Aug 7, 2020·Progress in Retinal and Eye Research·Chang Ho YoonMee Kum Kim
Feb 2, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Hiroyuki YazuHiroshi Fujishima
May 21, 2021·Indian Journal of Ophthalmology·Amrita MohantySrikant K Sahu
Aug 6, 2021·Therapeutic Advances in Ophthalmology·Lisa-Marie AndersMatthias C Grieshaber
Jun 19, 2009·Current Opinion in Ophthalmology

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