Long-term versus short-term introvesical chemotherapy in patients with non-muscle-invasive bladder cancer: a systematic review and meta-analysis of the published results of randomized clinical trials

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Teng LiMin Chen

Abstract

In order to assess the effect of long-term versus short-term intravesical chemotherapy in preventing the recurrence of patients with non-muscle-invasive bladder cancer, we searched several databases with words as mesh terms and free text words to find all eligible randomized clinical trials (RCTs) for the comparison of the two strategies of instillation durations. "Observed-Expected events research (O-E)" and "Variance (V)" for calculating hazard ratio (HR) were used in Revman 5.2 software recommended by Cochrane Collabration for data analysis. Sensitivity and subgroup analysis were selected to minish heterogeneity. GRADEpro 3.6 profile recommended by Cochrane Collabration was employed for quality assessment of analyses. Finally, 13 eligible RCTs with 4216 patients were included in this review and 16 comparisons from 13 trials were involved for analysis. The pooled analysis revealed no significant difference between long-term and short-term duration [HR=0.99, 95% CI (0.89, 1.11), P=0.89]. Within the subgroup analysis, patients benefited from long-term instillations with a start regimen of one immediate instillation [HR=0.83, 95% CI (0.69, 1.00), P=0.05]. But patients were not suitable to receive long-term instillations with epi...Continue Reading

References

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Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K H KurthWillem Oosterlinck
Apr 20, 2001·Journal of the National Cancer Institute·J L AuInternational Mitomycin C Consortium
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon H GuyattHolger J Schünemann
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattGRADE Working Group

Related Concepts

Intravesical Injection
Antibiotics, Cytotoxic
Malignant Neoplasm of Urinary Bladder
Pharmacotherapy
Neoplasm Recurrence, Local
Farmorubicina
Controlled Clinical Trials, Randomized
Clinical Trials
Epirubicin
Research

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