Long-Term Vitamin K Antagonists and Cancer Risk: A Systematic Review and Meta-Analysis

American Journal of Clinical Oncology
Mohammed ShurrabDennis T Ko

Abstract

Vitamin K antagonists (VKAs) remain one of the most commonly used anticoagulation therapies. The potential anticancer effect of long-term use of VKAs has been a matter of debate with conflicting results. Our goal was to perform a systematic review and meta-analysis examining the association between long-term VKAs use and cancer risk. Systematic searches of multiple major databases were performed from inception until January 2018. We included studies of adults that compared incidence of any cancer between ≥6 months use of VKAs (long-term group) and <6 months use of VKAs or nonuse (control group). Primary outcome was all-cancer incidence and secondary outcomes were cancer-specific incidence, all-cause death and cancer-specific mortality. Hazard ratios (HRs) were pooled using a random-effects model, and individual studies were weighted using inverse variance. We identified 9 observational studies that included 1,521,408 patients. No randomized trials were identified. In comparison to control, long-term use of VKAs was associated with a significant reduction in incidence of all cancers (HR, 0.84; 95% confidence interval [CI], 0.81-0.88; P<0.001). In a prespecified subgroup analysis, long-term use of VKAs demonstrated a significant ...Continue Reading

References

Jul 30, 1977·Lancet·V Egilsson
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Nov 1, 1982·Annals of Internal Medicine·L Zacharski
Feb 1, 1995·American Journal of Clinical Oncology·A CarpiA Nicolini
Jun 30, 2000·The New England Journal of Medicine·C C Zielinski, M Hejna
Oct 10, 2002·The Lancet Oncology·Graham J Caine, Gregory Y H Lip
Aug 13, 2003·Journal of Thrombosis and Haemostasis : JTH·M R TalianiWarfarin Optimal Duration Italian Trial (WODIT) Investigators
Mar 27, 2004·Thrombosis and Haemostasis·William A BlumentalsThomas J Mason
Apr 6, 2007·Cancer Treatment Reviews·V TagalakisSusan R Kahn
May 1, 2007·The Lancet Oncology·Henrik Toft Sørensen
Oct 22, 2008·Annals of Hematology·L EischerAUREC-FVIII investigators
Jul 23, 2009·Annals of Internal Medicine·David MoherPRISMA Group
May 15, 2010·Thrombosis Research·Vittorio PengoMartino F Pengo
Oct 16, 2012·International Journal of Cancer. Journal International Du Cancer·Anton PottegårdJesper Hallas
Jan 24, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yishen Wang, Beata Bajorek
Jun 21, 2014·Cancer Causes & Control : CCC·Audrey Blanc-LapierreMarie-Élise Parent
Jul 7, 2015·The American Journal of Medicine·Geoffrey D BarnesZachary D Goldberger
Oct 13, 2015·Annals of Internal Medicine·Albert L Siu, U.S. Preventive Services Task Force
Oct 20, 2015·Breast Cancer Research and Treatment·Jianguang JiKristina Sundquist
Jul 22, 2016·JAMA Cardiology·David ConenChristine M Albert
Sep 16, 2016·Scandinavian Journal of Urology·Pete T T KinnunenAnssi Auvinen
Apr 14, 2017·Journal of Thrombosis and Haemostasis : JTH·L EischerSabine Eichinger
Feb 24, 2018·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Gianpaolo PerlettiEmanuele Montanari

Citations

Related Concepts

Indirect Thrombin Inhibitors
Malignant Neoplasms
Vitamin K
Anticoagulation Therapy
Cessation of Life
Clinical Trials, Randomized
Meta Analysis (Statistical Procedure)
Subgroup
Observational Study
Venous Thromboembolism

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