Long-Term Weight Trajectory and Risk of Hip Fracture, Falls, Impaired Physical Function, and Death

Journal of the American Geriatrics Society
E S LeBlancStudy of Osteoporotic Fractures Research Group

Abstract

To determine the association between weight trajectory, health status, and mortality in older women. Cohort study. Study of Osteoporotic Fractures. Older community-dwelling women (age: baseline (1986-88), mean 68, range 65-81; Year 20 (2006-08), mean 88, range 83-102 (N = 1,323)). Body weight measured repeatedly over 20 years (mean 8 times). Logistic and Cox proportional hazard models were used to evaluate whether 20-year weight trajectory measures were associated with hip fracture, falls, physical performance, and mortality. In models adjusted for age, clinic, calcium use, Year 20 weight, walking speed, comorbidity score, smoking, self-reported health, and walking for exercise, women with moderate weight loss (>9.0 kg) over 20 years had a 74% greater risk of death (hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.37-2.20) in the 5 years after the Year 20 visit than those with no weight loss and more than twice the risk of hip fracture (HR = 2.56, 95% CI = 1.39-4.70). They were 3.6 times (odds ratio (OR) = 3.60, 95% CI = 1.86-6.95) as likely to have poor physical function at the Year 20 visit as women with no weight loss but no greater risk of 2 or more falls in the 1.5 years after the Year 20 visit. Weight variabilit...Continue Reading

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Citations

Aug 14, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David ScottVasant Hirani
Nov 18, 2020·Geriatrics & Gerontology International·Masafumi Kuzuya
Sep 27, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zhi YuJosef Coresh

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