PMID: 9430253Jan 16, 1998Paper

Long terminal repeat and nef gene variants of human immunodeficiency virus type 1 in perinatally infected long-term survivors and rapid progressors

AIDS Research and Human Retroviruses
C RousseauM C King

Abstract

HIV-1 sequences from perinatally infected children were analyzed in the long terminal repeat (LTR) region and nef in order to investigate associations of viral variation and disease progression. Four long-term survivors who reached 10 years of age or older, and four rapid progressors who survived less than 2 years, participated in this study. LTR sequences of multiple independent viral variants from each individual were compared. No sequence pattern within the LTR consistently distinguished long-term survivors from rapid progressors or vice versa. Deletions and insertions within transcription factor binding sites of the LTR and nef ranging from 8 to 341 bp were found in viral variants from the eldest long-term survivor (LTS047). These deletions and duplications may be associated with the survival of LTS047 via an unknown mechanism. Among all children in this study, the sites in the untranslated region (NF-kappaB, SP1, and TATA box) were more conserved than the sites in the nef/LTR overlap region (NFAT, purine-rich region, USF, TCF1alpha), reflecting the importance of the sites in the untranslated region for viral replication. A mutation in the E box motif within the USF site among the sequences from a long-term survivor (LTS113...Continue Reading

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C LiR B Gaynor
Jan 1, 1987·AIDS Research and Human Retroviruses·L RatnerF Wong-Staal
Apr 1, 1995·PCR Methods and Applications·E L DelwartJ I Mullins
Apr 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M L Newell, D M Gibb
May 1, 1993·Virology·E Zazopoulos, W A Haseltine
Aug 1, 1994·Trends in Microbiology·M D MillerW C Greene
Aug 1, 1993·Journal of Virology·D C ShugarsR Swanstrom

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Citations

Jan 24, 2002·AIDS Research and Human Retroviruses·P NovelliR S Daniels
Oct 14, 2003·Virology·Edward Reed-Inderbitzin, Wendy Maury
Sep 10, 2003·Journal of Leukocyte Biology·Olivier RohrEvelyne Schaeffer
Jul 27, 2001·Molecular Biology and Evolution·M AnisimovaZ Yang

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