Long terms trends in CD4+ cell counts, CD8+ cell counts, and the CD4+ :  CD8+ ratio

AIDS
Rachael A HughesJonathan Sterne

Abstract

Model trajectories of CD4+ and CD8+ cell counts after starting combination antiretroviral therapy (ART) and use the model to predict trends in these counts and the CD4+ : CD8+ ratio. Cohort study of antiretroviral-naïve HIV-positive adults who started ART after 1997 (ART Cohort Collaboration) with more than 6 months of follow-up data. We jointly estimated CD4+ and CD8+ cell count trends and their correlation using a bivariate random effects model, with linear splines describing their population trends, and predicted the CD4+ : CD8+ ratio trend from this model. We assessed whether CD4+ and CD8+ cell count trends and the CD4+ : CD8+ ratio trend varied according to CD4+ cell count at start of ART (baseline), and, whether these trends differed in patients with and without virological failure more than 6 months after starting ART. A total of 39 979 patients were included (median follow-up was 53 months). Among patients with baseline CD4+ cell count at least 50 cells/μl, predicted mean CD8+ cell counts continued to decrease between 3 and 15 years post-ART, partly driving increases in the predicted mean CD4+ : CD8+ ratio. During 15 years of follow-up, normalization of the predicted mean CD4+ : CD8+ ratio (to >1) was only observed amon...Continue Reading

References

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Citations

Dec 12, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Luuk GrasUNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)
Mar 27, 2020·The Journal of Antimicrobial Chemotherapy·Sabina HerreraSergio Serrano-Villar
May 9, 2021·Infection·Marco FloridiaUNKNOWN Italian Group on Surveillance of Antiretroviral Treatment in Pregnancy
Jun 19, 2021·Computational and Structural Biotechnology Journal·Wei LyuYu Kang

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