Longer aPTT values in healthy children than in adults: no single cause

Thrombosis Research
S GallistlW Meyers

Abstract

We have shown that activated partial thromboplastin time values in children are considerably longer than in adults, but the causes for this observation remained unclear. Therefore, we investigated the correlation between activated partial thromboplastin time values and concentrations of clotting factors, quotients and titers of the tissue thromboplastin inhibition test, and antiphospholipid antibodies in healthy children, children with recurrent infections, and adults. Concentrations of factors VIII, IX, and HMWK were significantly lower in children than in adults. Simple linear regression analysis failed to show a correlation between the concentration of a single clotting factor and the activated partial thromboplastin time values. No significant correlation was found between activated partial thromboplastin time and elevation of the tissue thromboplastin inhibition test quotients or titers, or antiphospholipid antibodies values. The determined activated partial thromboplastin time was best described by a function including all measured coagulation factors. Our study suggests, that no single clotting factor or lupus anticoagulants are responsible for the longer activated partial thromboplastin time in healthy children, but tha...Continue Reading

References

Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron, G Frampton
Jul 1, 1970·Acta paediatrica Scandinavica·H EkelundB Astedt
Nov 1, 1971·The Journal of Pediatrics·W A BleyerT H Shepard
Sep 1, 1996·Thrombosis Research·G EdlingerW Muntean

❮ Previous
Next ❯

Citations

Apr 9, 2001·Thrombosis Research·W Muntean, S Gallistl
Mar 4, 2000·Clinical and Laboratory Haematology·A M ConwayF Bell
Nov 7, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·N A GoldenbergM J Manco-Johnson
Oct 12, 2011·Journal of Thrombosis and Haemostasis : JTH·G M A van OsP G D E Groot
Aug 23, 2012·Journal of Thrombosis and Haemostasis : JTH·I M AppelA Beishuizen
Sep 24, 2004·Thrombosis Research·Patricia CasaisMaria A Lazzari
Nov 28, 2013·Pediatric Blood & Cancer·Brian R BranchfordMarilyn Manco-Johnson
May 16, 2015·International Journal of Laboratory Hematology·K A Moser, J Puetz
Aug 2, 2017·The American Journal of the Medical Sciences·Ke YaoDengju Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.