Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk

Journal of Neuro-oncology
Ivo S MuskensElizabeth B Claus

Abstract

Telomere length-associated SNPs have been associated with incidence and survival rates for malignant brain tumors such as glioma. Here, we study the influence of genetically determined lymphocyte telomere length (LTL) by comparing telomerase associated SNPs between the most common non-malignant brain tumor, i.e. meningioma, and healthy controls. One thousand fifty-three (1053) surgically treated meningioma patients and 4437 controls of Western European ancestry were included. Germline DNA was genotyped for 8 SNPs previously significantly associated with LTL. Genotypically-estimated LTL was then calculated by summing each SNP's genotypically-specified telomere length increase in base pairs (bp) for each person. Odds ratios for genotypically-estimated LTL in meningioma cases and controls were evaluated using logistic regression with the first two ancestral principal components and sex as covariates. Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39). Only rs9420907 remained significant after correction for multiple testing. Average genotypically-estimated LTL was s...Continue Reading

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Citations

Jul 14, 2019·Neuro-oncology·Quinn T OstromMelissa L Bondy
Sep 26, 2020·Frontiers in Oncology·Lianhua ZhaoZaiyu Guo
Oct 30, 2020·Acta Neuropathologica Communications·Chenan ZhangKyle M Walsh
Nov 25, 2021·Current Neurology and Neuroscience Reports·Quinn T OstromJill S Barnholtz-Sloan

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