Longer β oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism

Movement Disorders : Official Journal of the Movement Disorder Society
Marc DeffainsHagai Bergman

Abstract

The efficacy of deep brain stimulation (DBS) - primarily of the subthalamic nucleus (STN) - for advanced Parkinson's disease (PD) is commonly attributed to the suppression of pathological synchronous β oscillations along the cortico-thalamo-basal ganglia network. Conventional continuous high-frequency DBS indiscriminately influences pathological and normal neural activity. The DBS protocol would therefore be more effective if stimulation was only applied when necessary (closed-loop adaptive DBS). Our study aimed to identify a reliable biomarker of the pathological neuronal activity in parkinsonism that could be used as a trigger for adaptive DBS. To this end, we examined the oscillatory features of paired spiking activities recorded in three distinct nodes of the basal ganglia network of 2 African green monkeys before and after induction of parkinsonism (by MPTP intoxication). Parkinsonism-related basal ganglia β oscillations consisted of synchronized time-limited episodes, rather than a continuous stretch, of β oscillatory activity. Episodic basal ganglia β oscillatory activity, although prolonged in parkinsonism, was not necessarily pathological given that short β episodes could also be detected in the healthy state. Importan...Continue Reading

References

Jun 1, 1991·Molecular and Chemical Neuropathology·K A Jellinger
Jul 1, 1989·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D K McClish
Oct 15, 1998·The New England Journal of Medicine·P LimousinA L Benabid
Oct 21, 2000·Journal of Neuroscience Methods·G L Gerstein
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Aug 27, 2005·Brain : a Journal of Neurology·Wassilios MeissnerThomas Boraud
Nov 18, 2005·Experimental Neurology·Brett WingeierHelen M Bronte-Stewart
Apr 21, 2006·The European Journal of Neuroscience·Andrea A KühnPeter Brown
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gali HeimerHagai Bergman
Oct 5, 2006·Journal of Neural Transmission. Supplementum·P Brown
Nov 23, 2006·Current Biology : CB·Chiung Chu ChenPeter Brown
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Sep 21, 2007·The European Journal of Neuroscience·Arthur LebloisThomas Boraud
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea A KühnPeter Brown
May 23, 2009·Experimental Neurology·Moran WeinbergerJonathan O Dostrovsky
Feb 26, 2010·Journal of Neurophysiology·Choongseok ParkLeonid L Rubchinsky
Apr 3, 2010·Current Opinion in Neurobiology·Andreas K Engel, Pascal Fries
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mark W HoweAnn M Graybiel
Feb 14, 2012·Neuron·Daniel K LeventhalJoshua D Berke
Aug 28, 2012·Experimental Neurology·Edward Stein, Izhar Bar-Gad
May 29, 2013·NeuroImage·John-Stuart Brittain, Peter Brown
Jul 16, 2013·Annals of Neurology·Simon LittlePeter Brown
Apr 17, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allison T ConnollyJerrold L Vitek
Apr 25, 2015·PLoS Computational Biology·Ayala Matzner, Izhar Bar-Gad
Sep 29, 2015·Parkinsonism & Related Disorders·M Beudel, P Brown
Oct 2, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Simon LittlePeter Brown
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Joseph FeingoldAnn M Graybiel
Jan 29, 2016·Neurology·Vincent J J OdekerkenUNKNOWN NSTAPS study group
Apr 16, 2016·Parkinsonism & Related Disorders·Mattia ArlottiAlberto Priori
Jul 13, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Andrea A Kühn, Jens Volkmann
Jul 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Maxwell A ShermanStephanie R Jones
Aug 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Wolf-Julian NeumannAndrea A Kühn
Feb 17, 2017·Journal of Neurophysiology·Odeya MarmorRenana Eitan
Mar 24, 2017·Brain : a Journal of Neurology·Gerd TinkhauserPeter Brown
Oct 21, 2017·Brain : a Journal of Neurology·Gerd TinkhauserPeter Brown

❮ Previous
Next ❯

Citations

Oct 31, 2019·Brain : a Journal of Neurology·Matthew J GeorgiadesSimon J G Lewis
Feb 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Simon Little, Peter Brown
Feb 11, 2020·Brain : a Journal of Neurology·Saed KhawaldehPeter Brown
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jeremy W ChopekRobert M Brownstone
Jul 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hayriye CagnanAndrew Sharott
Sep 10, 2020·Frontiers in Systems Neuroscience·Cristóbal Moënne-LoccozRómulo A Fuentes-Flores
Mar 29, 2020·Nature Communications·Brice de la CrompeNicolas P Mallet
Jan 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Wolf-Julian NeumannR Mark Richardson
Nov 28, 2020·Nature Reviews. Neurology·Joachim K KraussAndres M Lozano
Nov 29, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher GüttlerChristoph van Riesen
Dec 11, 2020·Brain : a Journal of Neurology·Yasmine M KehnemouyiHelen M Bronte-Stewart
Mar 22, 2019·Neuron·Matthew M McGregor, Alexandra B Nelson
Apr 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Sohail Noor, Cameron C McIntyre
Jun 1, 2021·Frontiers in Neurology·Anna LatorreAnna Sadnicka
Jun 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Golan KarvatIlka Diester
Oct 15, 2020·Journal of Neural Engineering·Matteo VissaniAlberto Mazzoni
Jul 16, 2021·Neurodegenerative Disease Management·Daniel SiricaKarlo J Lizárraga
Oct 13, 2021·Annals of Clinical and Translational Neurology·Ross W AndersonHelen M Bronte-Stewart
Feb 1, 2022·Experimental Brain Research·Apoorva KarekalNicole C Swann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.