Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors.

The Lancet. Haematology
Stephen KaptogeINTERVAL Trial Group

Abstract

The INTERVAL trial showed that, over a 2-year period, inter-donation intervals for whole blood donation can be safely reduced to meet blood shortages. We extended the INTERVAL trial for a further 2 years to evaluate the longer-term risks and benefits of varying inter-donation intervals, and to compare routine versus more intensive reminders to help donors keep appointments. The INTERVAL trial was a parallel group, pragmatic, randomised trial that recruited blood donors aged 18 years or older from 25 static donor centres of NHS Blood and Transplant across England, UK. Here we report on the prespecified analyses after 4 years of follow-up. Participants were whole blood donors who agreed to continue trial participation on their originally allocated inter-donation intervals (men: 12, 10, and 8 weeks; women: 16, 14, and 12 weeks). They were further block-randomised (1:1) to routine versus more intensive reminders using computer-generated random sequences. The prespecified primary outcome was units of blood collected per year analysed in the intention-to-treat population. Secondary outcomes related to safety were quality of life, self-reported symptoms potentially related to donation, haemoglobin and ferritin concentrations, and defe...Continue Reading

Citations

Jan 9, 2020·Vox Sanguinis·A Mireille BaartElisabeth M J Huis In 't Veld
Apr 4, 2020·American Journal of Hematology·Alan E MastUNKNOWN NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III
Nov 27, 2020·Communications Biology·Maria DidriksenKari Stefansson
Mar 11, 2021·Health Economics·Kaat de CorteRichard Grieve
Aug 28, 2021·Healthcare·Amal Abdulsalam IbrahimAtiyeh M Abdallah

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Clinical Trials Mentioned

ISRCTN24760606
ISRCTN90871183

Software Mentioned

INTERVAL

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