Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin

Diabetes Research and Clinical Practice
Xi May ZhenChen Chen

Abstract

Insulin has traditionally been the gold standard pharmacological treatment for gestational diabetes mellitus (GDM). Insulin requires multiple injections a day, can cause frequent hypoglycaemia, requires careful handling, and is generally more expensive compared to oral agents. Metformin has been increasingly popular in recent years. Based on the short-term data available, metformin appears to be safe and effective for the treatment of GDM but existing studies have all stressed the lack of longer-term offspring data. This article will analyse the evidence available on the longer-term outcomes in the offspring of women with GDM treated with metformin versus insulin. Pubmed, EMBASE, CENTRAL, and CNKI were searched for follow-up studies of randomised controlled trials that compared metformin with insulin for the treatment of GDM. Existing follow-up studies did not find any significant increase in the risk of adverse effects in terms of growth and development in the offspring of GDM mothers managed with metformin versus insulin.

Citations

Sep 16, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Bülent AyasBahattin Avcı
Oct 20, 2018·International Journal of Molecular Sciences·Katarzyna E Skórzyńska-DziduszkoBożena Leszczyńska-Gorzelak

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