PMID: 698154Sep 1, 1978Paper

Longer though lighter menstrual and intermenstural bleeding with copper as compared to inert intrauterine devices

British Journal of Obstetrics and Gynaecology
J Guillebaud, J Bonnar


A randomized serial study of uterine blood loss was made of 281 women fitted with one of three intrauterine contraceptive devices (IUCDs): a Lippes loop D, a Dalkon shield or a Copper 7. The increase in the amount of blood loss was greatest with Lippes loop D users and least with Copper 7 users. However, the duration of menstrual and intermenstrual bleeding and of spotting was significantly greater among Copper 7 users than with the two inert devices. Thus the mechanisms whereby IUCDs increase the duration as opposed to the volume of uterine bleeding may be different. Previous users of oral contraceptives were found to have significantly less bleeding before IUCD insertion, but showed a similar pattern of increase of uterine bleeding after IUCD insertion to those who had not used oral contraceptives. For all three IUCDs, the increment in amount and duration of uterine bleeding after insertion decreased between the first and the sixth period, on average by about 15 ml and one to two days. No subsequent improvement was found and after 12 cycles the Copper 7 users had longer but less heavy uterine blood loss than users of the Lippes loop D.


Feb 21, 1976·Lancet·J GuillebaudA Matthews
Jan 1, 1978·British Journal of Obstetrics and Gynaecology·J GuillebaudA C Turnbull
Apr 29, 1977·Journal of Molecular Evolution·G W Moore, M Goodman
Oct 15, 1971·American Journal of Obstetrics and Gynecology·F K Beller
Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·L HALLBERG, L NILSSON
Jan 1, 1964·Acta Obstetricia Et Gynecologica Scandinavica·L HALLBERG, L NILSSON


Feb 1, 1976·British Journal of Obstetrics and Gynaecology·J BonnarM J Allington
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·D L EconomidesC A Lee
Feb 1, 1980·British Journal of Obstetrics and Gynaecology·B L Sheppard, J Bonnar
Aug 1, 1981·British Journal of Obstetrics and Gynaecology·G C ChristiaensA A Haspels
Mar 1, 1980·Pediatric Annals·D E Greydanus
Aug 8, 2014·Contact Dermatitis·Simon W FageJacob P Thyssen
Sep 3, 2020·Contact Dermatitis·Soumaya GaraFaten Zeglaoui
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Guillebaud
Jan 12, 1999·American Journal of Hematology·R A KadirC A Lee
Jun 17, 1997·Annals of the New York Academy of Sciences·E Deligeoroglou

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.