PMID: 9430522Jan 16, 1998Paper

Longevity of antibody responses to a Salmonella typhi-specific outer membrane protein: interpretation of a dot enzyme immunosorbent assay in an area of high typhoid fever endemicity

The American Journal of Tropical Medicine and Hygiene
K E ChooK H Ong

Abstract

The objective of this study was to investigate the longevity of positive dot enzyme immunosorbent assay (dot EIA) results for IgM and IgG to a Salmonella typhi outer membrane protein in Malaysian children with enteric fever. The patients were children one month to 12 years of age with clinical evidence of typhoid fever, positive blood or stool cultures for S. typhi, and/or a positive Widal test result who were admitted over a two-year period to General Hospital (Kota Bharu, Malaysia). These patients received standard inpatient treatment for enteric fever including chloramphenicol therapy for 14 days. Dot EIA tests were performed as part of clinical and laboratory assessments on admission, at two weeks, and then at 3, 6, 9, 12, 15, 18, and 21 months postdischarge. Assessment of the longevity of positive dot EIA IgM and IgG titers was done by Kaplan-Meier analysis. In 94 evaluable patients, 28% were dot EIA IgM positive but IgG negative on admission, 50% were both IgM and IgG positive, and 22% were IgM negative and IgG positive. Mean persistence of IgM dot EIA positivity was 2.6 months (95% confidence interval = 2.0-3.1 months) and that of IgG was 5.4 months (4.5-6.3 months). There were no significant differences between the thre...Continue Reading

Citations

Oct 23, 2018·Medicina·Olumide AjibolaAnthonius A Eze
May 26, 2017·The Cochrane Database of Systematic Reviews·Lalith WijedoruChristopher M Parry
Oct 19, 2017·Diagnostics·Chiuan Herng LeowJames McCarthy
Jun 2, 2020·PLoS Neglected Tropical Diseases·Mansyur ArifMuhammad Karyana

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