Longevity-Related Gene Transcriptomic Signature in Glioblastoma Multiforme

Oxidative Medicine and Cellular Longevity
Manal Said FawzyEman Ali Toraih

Abstract

Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state could explain some of the deregulated molecular signatures in GBM disease. The present study aimed to quantify the expression profiling of longevity-related transcriptional factors SOX2, OCT3/4, and NANOG to evaluate their diagnostic and performance values in high-grade gliomas. Forty-four specimens were obtained from glioblastoma patients (10 females and 34 males). Quantitative real-time polymerase chain reaction was applied for relative gene expression quantification. In silico network analysis was executed. NANOG and OCT3/4 mRNA expression levels were significantly downregulated while that of SOX2 was upregulated in cancer compared to noncancer tissues. Receiver operating characteristic curve analysis showed high diagnostic performance of NANOG and OCT3/4 than SOX2. However, the aberrant expressions of the genes studied were not associated with the prognostic variables in the current population. In conclusion, the current study highlighted the aberrant ...Continue Reading

References

Jul 21, 2001·Stem Cells·M Pesce, H R Schöler
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Sep 13, 2005·Cell·Laurie A BoyerRichard A Young
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dragan MaricJeffery L Barker
May 22, 2008·Neurochemical Research·Paola Dell'Albani
Mar 10, 2009·Biochemical and Biophysical Research Communications·Matthieu SchoenhalsBernard Klein
Jan 14, 2011·The Journal of Surgical Research·Junko MatsuokaKosei Hirakawa
Sep 13, 2012·Experimental and Therapeutic Medicine·Xiang ZhangYong-Qiang Zhang
Mar 1, 2013·The Biochemical Journal·Gerald Thiel
May 4, 2013·Stem Cells and Development·George S WilsonLiang Qiao
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Aug 13, 2014·Clinical and Translational Medicine·Kasia Weina, Jochen Utikal
May 11, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Andrew MorokoffAndrew H Kaye
Aug 11, 2015·Frontiers in Oncology·Tracy SeymourFoteini Kakulas
Nov 19, 2015·International Journal of Molecular Sciences·Tracy SeymourFoteini Kakulas
May 6, 2016·Frontiers in Surgery·Amy BradshawTinte Itinteang
Jun 28, 2016·Molecular Diagnosis & Therapy·Eman A ToraihMohamad M El-Labban
Nov 9, 2016·Frontiers in Oncology·Laura Garros-RegulezAnder Matheu

❮ Previous
Next ❯

Citations

Mar 12, 2019·The International Journal of Biological Markers·Eman A ToraihSomaya Hosny
May 21, 2020·Cells·Malak Hassn MesratiAmir Syahir
May 2, 2021·Journal of Clinical Laboratory Analysis·Nawal S GoudaEman A Toraih

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.