Longitudinal 2-point dixon muscle magnetic resonance imaging in becker muscular dystrophy

Muscle & Nerve
Ulrike BonatiDirk Fischer

Abstract

Quantitative MRI techniques detect disease progression in myopathies more sensitively than muscle function measures or conventional MRI. To date, only conventional MRI data using visual rating scales are available for measurement of disease progression in Becker muscular dystrophy (BMD). In 3 patients with BMD (mean age 36.8 years), the mean fat fraction (MFF) of the thigh muscles was assessed by MRI at baseline and at 1-year follow-up using a 2-point Dixon approach (2PD). The motor function measurement scale (MFM) was used for clinical assessment. The mean MFF of all muscles at baseline was 61.6% (SD 7.6). It increased by 3.7% to 65.3% (SD 4.7) at follow-up. The severity of muscle involvement varied between various muscle groups. As in other myopathies, 2PD can quantify fatty muscle degeneration in BMD and can detect disease progression in a small sample size and at relatively short imaging intervals.

References

Oct 1, 1984·Radiology·W T Dixon
Nov 19, 1983·Lancet·H M KingstonD Page
Jan 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·Y HuangR G Miller
Aug 18, 2005·Neuromuscular Disorders : NMD·Carole BérardUNKNOWN MFM Collaborative Study Group
May 21, 2009·Developmental Medicine and Child Neurology·Carole VuillerotCarole Berard
Apr 28, 2010·European Radiology·Mike P WattjesDirk Fischer
Dec 25, 2010·Journal of Magnetic Resonance Imaging : JMRI·Monika GloorDirk Fischer
Feb 3, 2012·Journal of Neurology·Arne FischmannDirk Fischer
Sep 26, 2012·Neuromuscular Disorders : NMD·Giorgio TascaEnzo Ricci
Nov 10, 2012·Journal of Neurology·Arne FischmannDirk Fischer
Oct 15, 2013·Journal of Magnetic Resonance Imaging : JMRI·Arne FischmannJohn S Thornton
Mar 25, 2014·Muscle & Nerve·Neda Faridian-AraghJohn A Carrino
Dec 3, 2014·Journal of the Neurological Sciences·Mauro MonforteGiorgio Tasca

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Citations

Jul 19, 2016·Current Opinion in Neurology·Dirk FischerMike P Wattjes
Nov 24, 2017·Scientific Reports·Andrea BarpElena Pegoraro
Aug 17, 2020·Current Opinion in Neurology·Claudia Nuñez-PeraltaJordi Díaz-Manera
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Marc-André WeberMike P Wattjes
Jul 3, 2017·Journal of Neurology·Jedrzej BurakiewiczKieren G Hollingsworth
Feb 26, 2019·Frontiers in Neurology·Matteo PaolettiMassimiliano Filosto
Apr 6, 2021·Journal of Neuromuscular Diseases·Anne-Katrin GüttschesLara Schlaffke
Jun 8, 2021·Frontiers in Neurology·Aisha M SheikhJohn Vissing

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