Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Brit MollenhauerPPMI study

Abstract

Aggregation of α-synuclein is central to the pathophysiology of PD. Biomarkers related to α-synuclein may be informative for PD diagnosis/progression. To analyze α-synuclein in CSF in drug-naïve PD, healthy controls, and prodromal PD in the Parkinson's Progression Markers Initiative. Over up to 36-month follow-up, CSF total α-synuclein and its association with MDS-UPDRS motor scores, cognitive assessments, and dopamine transporter imaging were assessed. The inception cohort included PD (n = 376; age [mean {standard deviation} years]: 61.7 [9.62]), healthy controls (n = 173; age, 60.9 [11.3]), hyposmics (n = 16; age, 68.3 [6.15]), and idiopathic rapid eye movement sleep behavior disorder (n = 32; age, 69.3 [4.83]). Baseline CSF α-synuclein was lower in manifest and prodromal PD versus healthy controls. Longitudinal α-synuclein decreased significantly in PD at 24 and 36 months, did not change in prodromal PD over 12 months, and trended toward an increase in healthy controls. The decrease in PD was not shown when CSF samples with high hemoglobin concentration were removed from the analysis. CSF α-synuclein changes did not correlate with longitudinal MDS-UPDRS motor scores or dopamine transporter scan. CSF α-synuclein decreases ear...Continue Reading

References

Aug 26, 2006·Biochemical and Biophysical Research Communications·Takahiko TokudaOmar M A El-Agnaf
Sep 27, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Karin Stiasny-KolsterWolfgang H Oertel
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Clemens R ScherzerMichael G Schlossmacher
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Feb 17, 2010·Brain : a Journal of Neurology·Zhen HongJing Zhang
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Sep 21, 2011·Progress in Neurobiology·UNKNOWN Parkinson Progression Marker Initiative
Apr 18, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Brian SpencerEliezer Masliah
Jun 2, 2012·Sleep·Birgit FrauscherUNKNOWN SINBAR (Sleep Innsbruck Barcelona) Group
Sep 11, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Richard H SwartzUNKNOWN University of Toronto Stroke Program Investigators
Mar 15, 2014·The American Journal of Pathology·Tessandra StewartUNKNOWN Parkinson Study Group DATATOP Investigators
Aug 14, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Mike A NallsUNKNOWN Parkinson's Progression Marker Initiative (PPMI) investigators
Dec 9, 2015·Biomarkers in Medicine·Lucilla ParnettiDavide Chiasserini
Feb 18, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Sara HallOskar Hansson
Mar 25, 2016·Parkinsonism & Related Disorders·L M ChahineD Weintraub
May 11, 2016·Neurology·Brit MollenhauerUNKNOWN DeNoPa Study Group
Aug 23, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Nour K MajbourOmar M A El-Agnaf
Oct 19, 2016·Annals of Clinical and Translational Neurology·Graham FairfoulAlison J E Green
May 19, 2017·PloS One·Chelsea Caspell-GarciaUNKNOWN Parkinson’s Progression Markers Initiative (PPMI)
Jun 9, 2017·JAMA Neurology·Danna JenningsUNKNOWN PARS Investigators
Sep 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo EusebiLucilla Parnetti
Oct 13, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D James SurmeierGlenda M Halliday
Oct 17, 2017·Neurology·Brit MollenhauerUNKNOWN Parkinson's Progression Marker Initiative
Feb 8, 2018·Parkinsonism & Related Disorders·Marthe Gurine FørlandJohannes Lange
Feb 23, 2018·Molecular Neurodegeneration·Kaoru Yamada, Takeshi Iwatsubo
Mar 28, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Courtney L SutphenUNKNOWN ADNI
May 10, 2019·Journal of Neurochemistry·Leonidas StefanisGeorge K Tofaris

❮ Previous
Next ❯

Citations

Mar 3, 2020·Critical Reviews in Clinical Laboratory Sciences·Darren M O'HaraLorraine V Kalia
Mar 10, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M NiuJ Liu
Jan 21, 2020·Journal of Neurochemistry·Inês Caldeira BrásTiago Fleming Outeiro
Sep 20, 2020·Annals of Clinical and Translational Neurology·Xiao-Tong WangJin-Tai Yu
Jul 1, 2020·Neural Regeneration Research·Gabriella Caminati, Piero Procacci
May 28, 2020·Frontiers in Neurology·Eldbjørg Hustad, Jan O Aasly
Mar 29, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Sophia R L VieiraAnthony H V Schapira
May 7, 2020·Frontiers in Neuroscience·Maja MalmbergKariem Ezzat
Dec 16, 2020·Annals of Clinical and Translational Neurology·Lana M ChahineAlex Iranzo
Feb 7, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Stefanie LercheKathrin Brockmann
Nov 14, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·David DevosRichard Wyse
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Kathrin Brockmann
Apr 22, 2021·Metabolic Brain Disease·Banabihari GiriChandramohan Wakade
May 13, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Nour K MajbourOmar El-Agnaf
Jun 20, 2021·Lancet Neurology·Nirosen VijiaratnamThomas Foltynie
Jul 3, 2021·Behavioral Sciences·Ángela Milán-TomásMaría Cruz Rodríguez-Oroz
Jun 29, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Stefanie LercheKathrin Brockmann
Jul 21, 2021·ACS Chemical Neuroscience·Siwei ChenAmal Alachkar
Jul 22, 2021·Scientific Reports·Min Seok BaekChul Hyoung Lyoo
Jul 28, 2021·NPJ Parkinson's Disease·Luis M A OliveiraTiago F Outeiro

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Clinical Trials Mentioned

NCT01141023

Software Mentioned

SAS
DaTscan
RNA Integrity Number

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.