PMID: 7545928Jun 1, 1994Paper

Longitudinal analysis of hepatitis C virus infection and genetic drift of the hypervariable region

The Journal of Infectious Diseases
L J van DoornK Murray

Abstract

Hepatitis C virus (HCV) infections in a cohort of chimpanzees were studied retrospectively. All animals had been inoculated intravenously with materials derived from a single-source chimpanzee plasma implicated in non-A, non-B hepatitis, prepared by extensive ultracentrifugation. Anti-HCV and HCV RNA were monitored by the confirmatory line immunoassay and by an RNA-capture polymerase chain reaction method, respectively. In a chronically infected chimpanzee, HCV RNA was detectable after 32 days and throughout the acute phase, dropped transiently below detection level, and became detectable again. In 3 other chimpanzees with acute resolving infections, HCV RNA was detected 7-11 days after inoculation and became permanently undetectable after alanine aminotransferase normalization. Various anti-HCV profiles were detected among the chimpanzees. Analysis of the hypervariable region in E2/NS1 in 7 chimpanzees suggested genome stability on transmission, revealed different mutation frequencies during chronic infection, and suggested the importance of immune selection during chronic HCV infection.

Citations

Aug 1, 1996·Journal of Medical Virology·X de LamballerieP De Micco
Aug 1, 1994·Journal of Medical Virology·L J van Doorn
May 9, 2008·PloS One·Nathan A CannonUNKNOWN Virahep-C Study Group
Aug 8, 2006·Protein Expression and Purification·Marija MihailovaPaul Pumpens
Mar 18, 2015·Viruses·Livia Maria Gonçalves RossiPaula Rahal
Jan 28, 2015·World Journal of Hepatology·Babs E VerstrepenGerrit Koopman
Dec 5, 2014·World Journal of Gastroenterology : WJG·Maria Victoria PreciadoMayra Cruz-Rivera
Jul 1, 1995·Journal of Clinical Microbiology·J OdebergJ Lundeberg

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