PMID: 9427882Jan 15, 1998Paper

Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis

The Journal of Pediatrics
M CoreyMichael R Knowles

Abstract

Chronic progressive lung disease is the most prominent cause of morbidity and death in patients with cystic fibrosis (CF), but severity of lung disease and rate of lung function decline are widely variable. Accurate estimates of decline have been difficult to define and compare because the timing of measurements and duration of follow-up differ in various patient groups. Three hundred sixty-six patients with CF, born from 1960 to 1974, were selected from a CF database birth cohort if they had two or more measurements of pulmonary function, at least one of which was performed before the age of 10 years. Mixed model regression analysis provided estimates of the average rate of decline of spirometry measurements in subgroups on the basis of survival age, sex, pancreatic status, and genotype. Patients who died before the age of 15 years had significantly poorer pulmonary function when first tested and a more rapid decline in pulmonary function thereafter than patients who survived beyond the age of 15 years. In the latter, functional levels at the age of 5 years were normal, but average rates of decline were significantly related to survival age. Female patients had significantly steeper decline than male patients, and those with p...Continue Reading

Citations

Jan 31, 2008·JAMA : the Journal of the American Medical Association·J Michael CollacoGarry R Cutting
Sep 6, 2000·Pediatric Pulmonology·W Robinson, D A Waltz
Feb 17, 2001·Pediatric Pulmonology·A SmythR Smyth
Jul 12, 2002·Statistics in Medicine·Mark D SchluchterPamela B Davis
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Omar M PirzadaMark L Everard
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Bigna M KellerMartin H Schöni
May 23, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michael W KonstanDonald R VanDevanter
Jun 17, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Dorota SandsSusan Madge
Jun 18, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·K De BoeckUNKNOWN ECFS-CTN network partners
Jan 26, 2008·International Journal of Technology Assessment in Health Care·Denise N GuerrierePeter C Coyte
Oct 7, 2005·The New England Journal of Medicine·Mitchell L DrummUNKNOWN Gene Modifier Study Group
Apr 30, 2005·Journal of Palliative Medicine·W Robinson
Feb 24, 2001·American Journal of Epidemiology·T G LiouB C Marshall
Oct 29, 2004·Current Opinion in Pulmonary Medicine·Carlos E Milla
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Michael R Knowles
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Harm A W M Tiddens, Pim A de Jong
Jan 5, 2002·Biometrics·L J EdwardsR W Helms
Jul 26, 2005·Archives of Disease in Childhood·S M JavadpourA L Coates
Dec 13, 2006·Journal of Medical Genetics·Kitti BuranawutiGarry R Cutting
Sep 1, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aliye UcMichael J Welsh
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·D D FrangoliasP G Wilcox
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·M S SchechterS C Fitzsimmons
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Paulo J C MarosticaRobert S Tepper
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonClaude Gaultier
May 15, 2003·American Journal of Respiratory and Critical Care Medicine·Terry E RobinsonRichard B Moss
Jun 28, 2003·American Journal of Respiratory and Critical Care Medicine·Helen L WallaceKevin W Southern
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Peadar G NooneMichael R Knowles
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonBonnie W Ramsey
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·David M RodmanJerry A Nick
Nov 9, 2004·American Journal of Respiratory and Critical Care Medicine·Richard KraemerSabina Gallati
Jul 22, 2006·American Journal of Respiratory and Critical Care Medicine·Mark D SchluchterMichael R Knowles
Sep 9, 2006·American Journal of Respiratory and Critical Care Medicine·Richard KraemerReto Crameri
Mar 3, 2007·American Journal of Respiratory and Critical Care Medicine·Lori L VanscoyGarry R Cutting
Sep 9, 2008·American Journal of Respiratory and Critical Care Medicine·Joanna E MacLeanPadmaja Subbarao
May 14, 2010·American Journal of Respiratory and Critical Care Medicine·Don B SandersChristopher H Goss
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Sanjay H ChotirmallNoel G McElvaney
Jul 9, 2011·American Journal of Respiratory and Critical Care Medicine·Don B SandersPhilip M Farrell
Nov 19, 2011·American Journal of Respiratory and Critical Care Medicine·Bruce C TrapnellUNKNOWN Phase 2 FTI Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.