Longitudinal analysis of resting energy expenditure in patients with cystic fibrosis

The Journal of Pediatrics
Annabel MagoffinK J Gaskin

Abstract

To assess whether elevated resting energy expenditure (REE) in female patients with cystic fibrosis (CF) persists longitudinally during late childhood and puberty. REE and body composition were measured 3 times in 2 years in 86 children with CF. Pubertal status, bacterial colonization, liver disease, pancreatic and pulmonary function, and genotype were determined, and linear mixed model analyses were used to determine predictors and changes in REE longitudinally. REE did not change with time allowing for fat free mass, pancreatic insufficiency (PI), or severe mutations. Pulmonary function and liver disease were not significant predictors of REE. Percentage predicted REE compared with control data was higher (P = .002) in female patients with CF (109.5%) and lower in male patients with CF (104%) and persisted with time. In post-menarchal female patients with CF, REE adjusted for fat free mass was 366 kJ/d lower than in pre-menarchal female patients, but still 112% predicted. This longitudinal study demonstrates that REE is elevated in patients with CF with PI and severe mutations. The elevation of percentage predicted REE was greater in female patients than male patients and persisted for 2 years, and during pubertal maturation,...Continue Reading

References

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Citations

Mar 7, 2013·European Journal of Clinical Nutrition·K J Gaskin
Sep 11, 2012·Orphanet Journal of Rare Diseases·Pierre-Yves BoëlleUNKNOWN European CF Registry Working Group
Feb 10, 2016·Clinics in Chest Medicine·Missale SolomonMaria R Mascarenhas
Aug 8, 2015·Digestive Diseases and Sciences·Drucy BorowitzSarah Jane Schwarzenberg
Nov 26, 2009·Pediatric Clinics of North America·Suzanne H MichelMaria Mascarenhas
Sep 10, 2011·Pediatric Pulmonology·Michael S StalveyDavid E Geller
Jun 1, 2011·Pediatric Pulmonology·Stacey L SimonKristin A Riekert
Jan 15, 2015·Journal of Gastroenterology and Hepatology·Wolfram HallerMark Oliver
Feb 13, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Veronique GroleauVirginia A Stallings
May 17, 2019·Expert Review of Respiratory Medicine·Carla ColomboGianfranco Alicandro
Jul 23, 2019·The Cochrane Database of Systematic Reviews·Deirdre ShimminTracey Remmington
Dec 10, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Eran LaviDavid Zangen
Apr 10, 2015·The Cochrane Database of Systematic Reviews·Alison Morton, Susan Wolfe

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