Longitudinal analysis of T-cell receptor variable beta chain repertoire in patients with acute graft-versus-host disease after allogeneic stem cell transplantation

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Congxiao LiuNelson J Chao

Abstract

T-cell receptor variable beta chain (TCRBV) repertoire spectratyping involves the estimation of CDR3 length distributions for monitoring T-cell receptor diversity and has proven useful for analyses of immune reconstitution and T-cell clonal expansions in graft-versus-host disease (GVHD) and graft-versus-leukemia after allogeneic stem cell transplantation. We performed a longitudinal spectratype analysis of 23 TCRBV families in 28 patients who underwent allogeneic T cell-depleted peripheral blood stem cell transplantation. Sixteen patients subsequently developed acute GVHD. We recently developed statistical methods that bring increased power and flexibility to spectratype analysis and allow us to analyze TCRBV repertoire development under appropriately complex statistical models. Applying these methods, we found that patients with acute GVHD demonstrated TCRBV repertoire development statistically distinct from that repertoire development in patients without GVHD. Specifically, GVHD patients showed spectratypes indicative of lower diversity and greater deviation from the spectratypes expected in healthy individuals at intermediate times. Most individual TCRBV subfamilies had spectratypes statistically distinguishable between GVHD...Continue Reading

References

Mar 7, 1991·The New England Journal of Medicine·J L Ferrara, H J Deeg
Sep 1, 1986·British Journal of Haematology·M K BrennerH G Prentice
Jun 3, 1999·The New England Journal of Medicine·E C GuinanJ G Gribben
Jun 16, 2005·Bioinformatics·Thomas B KeplerM Louise Markert

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Citations

Dec 12, 2012·Critical Reviews in Oncology/hematology·Claudio Fozza, Maurizio Longinotti
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jenny ZilberbergRobert Korngold
Nov 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jinwei DuPing Zhu
Dec 19, 2014·Frontiers in Immunology·Amir A ToorMichael C Neale
Feb 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Omid ShahEverett H Meyer
May 18, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mark LeickYi-Bin Chen
Jan 25, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeremy A MeierAmir A Toor

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