Longitudinal assessment of awareness in early-stage Alzheimer's disease using comparable questionnaire-based and performance-based measures: a prospective one-year follow-up study

Aging & Mental Health
Linda Clare, B A Wilson

Abstract

Few studies of awareness in dementia have taken a longitudinal perspective, yet exploring the ways in which awareness changes over time may offer important information about the processes involved and the relationship between awareness and other variables. The present study explored in detail the patterns of change in awareness scores over time for a group of 12 participants with early-stage Alzheimer's disease using a multi-dimensional measure giving comparable participant-carer and post diction-performance discrepancy scores. There were small, non-significant increases in mean discrepancy scores for each of these components of the assessment, with similar patterns for questionnaire-based and performance-based ratings. The small changes that were observed reflected both participant and informant factors. The majority of participants showed only very minor changes; others showed changes in the direction of either reduced or increased awareness. There was no significant association between change in mean discrepancy score and change in MMSE score over time, although there was a significant decline in MMSE scores at follow-up. The observation of different longitudinal trajectories for awareness scores, reflecting increased or dec...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1992·Clinics in Geriatric Medicine·S I Kramer, B V Reifler
Jun 1, 1992·The Australian and New Zealand Journal of Psychiatry·J BowersP Harris
Oct 1, 1991·Journal of Geriatric Psychiatry and Neurology·C A MangoneW C Dollear
Jul 1, 1991·Journal of Clinical and Experimental Neuropsychology·G J LarrabeeT H Crook
Mar 1, 1990·Journal of Clinical and Experimental Neuropsychology·B H DeBettigniesF J Pirozzolo
Jul 1, 1994·Journal of Geriatric Psychiatry and Neurology·D H Jacobson, C H Winograd
Sep 26, 1997·Alzheimer Disease and Associated Disorders·M M Neundorfer
Jul 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·S E StarksteinR Leiguarda
Dec 23, 1999·International Journal of Geriatric Psychiatry·C DerouesnéL Lacomblez
Jun 1, 2004·The British Journal of Clinical Psychology·Linda Clare
Jun 1, 2004·The British Journal of Clinical Psychology·Linda Clare
Jun 19, 2004·Journal of Clinical and Experimental Neuropsychology·Linda ClareJohn R Hodges
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Wilson

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Citations

Sep 13, 2011·Alzheimer Disease and Associated Disorders·Linda ClareRobin G Morris
Jul 31, 2014·International Psychogeriatrics·Asmus VogelGunhild Waldemar
Dec 8, 2015·Neuroscience and Biobehavioral Reviews·Federica PirasGianfranco Spalletta
Mar 31, 2009·Journal of Gerontological Nursing·Janet K Pringle SpechtAnn L Bossen
Mar 6, 2009·Geriatrics & Gerontology International·Tomotaka AkaiToshihiko Iwamoto
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Oriol Turró-GarrigaJosep Lluís Conde-Sala
Aug 28, 2015·Neurology·Robert S WilsonJulie A Schneider
Jun 1, 2016·Journal of Clinical and Experimental Neuropsychology·Deepti Putcha, Geoffrey Tremont
Jul 22, 2016·Current Neurology and Neuroscience Reports·Robert S WilsonPatricia A Boyle
Jun 2, 2009·Journal of Clinical and Experimental Neuropsychology·Thomas M AtkinsonRobert Coder
May 17, 2008·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Lan Yao, Donna Algase
Nov 22, 2019·Annals of Neurology·Bernard J HanseeuwUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 9, 2020·American Journal of Alzheimer's Disease and Other Dementias·Amandine MayellePascal Antoine
Aug 12, 2020·International Journal of Qualitative Studies on Health and Well-being·Kirsten ThorsenAud Johannessen
Mar 12, 2017·Current Neurology and Neuroscience Reports·Preeti Sunderaraman, Stephanie Cosentino
Feb 17, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Teresa ParraoSergio E Starkstein

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