Feb 17, 2015

Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies

NeuroImage. Clinical
Elijah MakJohn T O'Brien

Abstract

Percent whole brain volume change (PBVC) measured from serial MRI scans is widely accepted as a sensitive marker of disease progression in Alzheimer's disease (AD). However, the utility of PBVC in the differential diagnosis of dementia remains to be established. We compared PBVC in AD and dementia with Lewy bodies (DLB), and investigated associations with clinical measures. 72 participants (14 DLBs, 25 ADs, and 33 healthy controls (HCs)) underwent clinical assessment and 3 Tesla T1-weighted MRI at baseline and repeated at 12 months. We used FSL-SIENA to estimate PBVC for each subject. Voxelwise analyses and ANCOVA compared PBVC between DLB and AD, while correlational tests examined associations of PBVC with clinical measures. AD had significantly greater atrophy over 1 year (1.8%) compared to DLB (1.0%; p = 0.01) and HC (0.9%; p < 0.01) in widespread regions of the brain including periventricular areas. PBVC was not significantly different between DLB and HC (p = 0.95). There were no differences in cognitive decline between DLB and AD. In the combined dementia group (AD and DLB), younger age was associated with higher atrophy rates (r = 0.49, p < 0.01). AD showed a faster rate of global brain atrophy compared to DLB, which had ...Continue Reading

Mentioned in this Paper

Mini-mental State Examination
Biological Markers
Neuro-Oncological Ventral Antigen 2
Imaging Studies
Unified Parkinson's Disease Rating Scale Questionnaire
Brain Injuries
Familial Alzheimer Disease (FAD)
Fluctuation
SNCA gene
Cerebral Atrophy

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