Longitudinal assessment of inflammation in recipients of continuous-flow left ventricular assist devices

The Canadian Journal of Cardiology
Liza Grosman-RimonVivek Rao

Abstract

The long-term effects of continuous-flow left ventricular assist device (CF-LVAD) support on trends of inflammatory markers over time are unknown. We examined the hypothesis that the levels of inflammatory markers in CF-LVAD recipients are higher than in healthy controls and that these levels increase over time with long-term CF-LVAD support. We examined the levels of inflammatory markers longitudinally at baseline before CF-LVAD implantation and at 3, 6, and 9 months after implantation. We then compared the levels of inflammatory markers to those in a healthy control group. Compared with baseline values before CF-LVAD implantation, left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd) decreased significantly at 3, 6, and 9 months after CF-LVAD implantation. Brain natriuretic peptide (BNP) levels dropped significantly after CF-LVAD implantation but did not normalize. Improvements in ejection fraction at 3, 6, and 9 months after CF-LVAD implantation did not reach significance. Monocyte chemoattractant protein-1, interferon γ-induced protein, and C-reactive protein levels were higher in the CF-LVAD recipients at each of the time points (baseline before CF-LVAD implantation and 3, 6, an...Continue Reading

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Citations

Oct 21, 2016·Current Heart Failure Reports·Shweta R Motiwala, Hanna K Gaggin
Nov 4, 2016·Expert Review of Medical Devices·Van-Khue TonVeli K Topkara
Nov 23, 2016·Expert Review of Medical Devices·Karolina K MarinescuDaniel Burkhoff
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Mar 27, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carlos FerreraGuy A MacGowan
Nov 26, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Liza Grosman-RimonVivek Rao
Dec 1, 2018·Frontiers in Immunology·Gemma RadleyCatherine A Thornton
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Liza Grosman-RimonVivek Rao
Feb 3, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jaya BatraVeli K Topkara

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