Longitudinal assessment of local and global functional connectivity following sports-related concussion

Brain Imaging and Behavior
Timothy B MeierAndrew Mayer

Abstract

Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N = 43) was assessed approximately one day (1.74 days post-injury, N = 34), one week (8.44 days, N = 34), and one month post-concussion (32.47 days, N = 30). Healthy contact sport-athletes served as controls (N = 51). Concussed athletes showed improvement in mood symptoms at each time point (p's < 0.05), but had significantly higher mood scores than healthy athletes at every time point (p's < 0.05). In contrast, self-reported symptoms and cognitive deficits improved over time following concussion (p's < 0.001), returning to healthy levels by one week post-concussion. ReHo in sensorimotor, visual, and temporal cortices increased over time post-concussion, and was greatest at one month post-injury. Conversely, ReHo in the fronta...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Kevin M GuskiewiczJames P Kelly
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Michael McCreaJames P Kelly
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Jun 8, 2004·Journal of Biomechanical Engineering·Liying ZhangAlbert I King
Nov 23, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Alison CernichJoseph Bleiberg
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Mar 31, 2007·Behavior Research Methods·David R Thorne
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Sep 19, 2008·Journal of Neurophysiology·Justin L VincentRandy L Buckner
Dec 18, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eugene ParkAndrew J Baker
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMarcus E Raichle
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Nov 17, 2009·NeuroImage·Michael W ColeWalter Schneider
Jun 16, 2010·PLoS Computational Biology·Jorge SepulcreRandy L Buckner
Mar 10, 2011·The Journal of Head Trauma Rehabilitation·Henry L LewAnn M Hendricks
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Jul 14, 2012·Brain : a Journal of Neurology·Stephen J GottsAlex Martin
Dec 19, 2012·Frontiers in Cellular Neuroscience·Zachary R Patterson, Matthew R Holahan
Jan 24, 2013·Journal of Rehabilitation Research and Development·Terri K PogodaHenry L Lew
Feb 5, 2013·NeuroImage·Gang ChenRobert W Cox
Feb 21, 2013·Journal of Neurotrauma·Daniel R SeichepineRobert A Stern
Jul 28, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tresa M Roebuck-SpencerDouglas B Cooper
Aug 29, 2013·Brain Connectivity·Paul A Taylor, Ziad S Saad
Jul 11, 2014·Journal of Neurotrauma·Michael BorichNaznin Virji-Babul
Jul 11, 2014·Journal of Neurotrauma·Brian JohnsonSemyon Slobounov
Aug 13, 2014·Brain Imaging and Behavior·Suzanne M CzerniakConstance M Moore
Sep 19, 2014·Neurosurgery·Christopher C Giza, David A Hovda
Dec 2, 2014·Neuroscience and Biobehavioral Reviews·Andrew R MayerFaith M Hanlon

❮ Previous
Next ❯

Citations

Aug 25, 2018·Journal of the International Neuropsychological Society : JINS·Donna L MurdaughThomas G Burns
Nov 20, 2018·Human Brain Mapping·Mayank KaushalTimothy B Meier
Mar 13, 2019·Research in Sports Medicine·Debbie I CraigAnn H Huffman
Oct 25, 2017·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Christina L MasterMatthew F Grady
Oct 22, 2019·Human Brain Mapping·Harm J van der HornJoukje van der Naalt
Jun 28, 2020·Journal of Magnetic Resonance Imaging : JMRI·David D StephensonAndrew R Mayer
Jan 8, 2021·Acta Neuropathologica Communications·Xuan Vinh To, Fatima A Nasrallah
May 11, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tamara L BakerSandy R Shultz

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA

Software Mentioned

Advanced Normalization Tools ( ANTS )
ANTS
3dTcorrMap
AFNI
ANAM
3dLME
Freesurfer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.