Abstract
We aimed to determine the surveillance performance of alpha-fetoprotein (AFP), lectin-reactive AFP (AFP-L3), des-gamma-carboxy prothrombin (DCP), and their combinations for the early detection of hepatocellular carcinoma (HCC) by using prospectively collected longitudinal samples in patients at risk. Among 689 patients with cirrhosis and/or chronic hepatitis B who participated in four prospective studies, 42 HCC cases were diagnosed, selected, and matched with 168 controls for age, sex, etiology, cirrhosis, and duration of follow-up in a 1:4 ratio. Levels of AFP, AFP-L3, and DCP at the time of HCC diagnosis, month -6, and month -12 were compared between cases and controls. Of 42 HCC cases, 39 (93%) had cirrhosis, 36 (85.7%) had normal alanine aminotransferase levels, and 31 (73.8%) had very early-stage HCC (single <2 cm). AFP and AFP-L3 began to increase from 6 months before diagnosis of HCC in cases (P < 0.05), while they remained unchanged in controls. At HCC diagnosis, the area under the receiver operator characteristic curves (AUROCs) for AFP, AFP-L3, and DCP were 0.77, 0.73, and 0.71, respectively. Combining AFP and AFP-L3 showed a higher AUROC (0.83), while adding DCP did not further improve the AUROC (0.86). With the opt...Continue Reading
References
Nov 15, 1989·Cancer·A M Di Bisceglie, J H Hoofnagle
Dec 22, 1998·The American Journal of Gastroenterology·N BayatiS C Gordon
Jul 19, 2001·Journal of the National Cancer Institute·M S PepeY Yasui
Oct 9, 2002·Statistics in Medicine·John S PreisserPaul J Rathouz
Jul 2, 2003·European Radiology·Wei Chiang LiuHyo Keun Lim
Jul 20, 2006·The American Journal of Gastroenterology·Shinichiro NakamuraYasushi Shiratori
Nov 17, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tito LivraghiSandro Rossi
Apr 14, 2009·Gastroenterology·Jorge A MarreroMyron Schwartz
Apr 25, 2009·Scandinavian Journal of Gastroenterology·Young Joon YoonDo Young Kim
Jun 2, 2009·Gastroenterology·Alejandro FornerJordi Bruix
Oct 27, 2009·Gastroenterology·Anna S LokUNKNOWN HALT-C Trial Group
Mar 12, 2010·Epidemiology·Alan E HubbardWilliam A Satariano
Aug 31, 2010·American Journal of Epidemiology·Peter C Austin
Jan 20, 2011·Cancer Science·Hidenori ToyodaShinji Satomura
Jun 22, 2011·Clinics in Liver Disease·Morris Sherman
Aug 11, 2011·Digestive Diseases·Masatoshi KudoUNKNOWN HCC Expert Panel of Japan Society of Hepatology
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Young-Suk LimDong Jin Suh
Jan 23, 2013·The American Journal of Gastroenterology·Amit G SingalWilliam M Lee
Apr 19, 2013·Digestive Diseases and Sciences·Yasushi TamuraYutaka Aoyagi
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Grace L H WongVincent W S Wong
Dec 4, 2014·Lancet·Claudia AllemaniUNKNOWN CONCORD Working Group
Jan 18, 2015·Gut·Young-Suk LimYung Sang Lee
Jan 28, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihiro KokudoMasatoshi Makuuchi
Mar 25, 2015·Gut·Young-Suk LimYung Sang Lee
Jun 24, 2015·Journal of Hepatology·Suzanne van MeerKarel J van Erpecum
Sep 5, 2015·Scandinavian Journal of Gastroenterology·Tae Seop LimSang Hoon Ahn
Nov 14, 2015·Hepatology International·S K SarinJ H Kao
Jan 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sarah BerhanePhilip Johnson
Sep 23, 2016·JAMA Oncology·So Yeon KimYung Sang Lee
Dec 6, 2016·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Jan 22, 2017·Seminars in Diagnostic Pathology·Justin HartkeMarwan Ghabril
Jan 29, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie K HeimbachJorge A Marrero
Feb 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin CadierUNKNOWN ANRS CO12 CirVir and CHANGH groups
Mar 12, 2017·Gastroenterology·Marina SerperUNKNOWN VOCAL Study Group
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Henry L Y ChanUNKNOWN GS-US-320-0110 Investigators
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Maria ButiUNKNOWN GS-US-320-0108 Investigators
Jun 15, 2017·Journal of Gastroenterology and Hepatology·Bo Hyun KimJae Seok Hwang
Oct 7, 2017·JAMA Oncology·UNKNOWN Global Burden of Disease Liver Cancer CollaborationChristina Fitzmaurice
Jan 10, 2018·Hepatobiliary Surgery and Nutrition·Di-Yang XieQiang Gao
Feb 10, 2018·Gastroenterology·Kristina TzartzevaAmit G Singal
Citations
Jul 20, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro LoglioPietro Lampertico
Feb 26, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yuan ChengMingXin Pan
Mar 30, 2019·Clinical and Molecular Hepatology·Ju Dong Yang
Feb 15, 2020·The Journal of International Medical Research·Zhaobo LiuNing Li
Apr 18, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandro LoglioPietro Lampertico
Jun 5, 2020·Cells·Federico PiñeroMário G Pessôa
Jun 17, 2020·Clinical and Molecular Hepatology·Takako Inoue, Yasuhito Tanaka
Apr 3, 2020·International Journal of Oncology·Yu-Xue GaoDe-Xi Chen
Aug 28, 2020·Journal of Viral Hepatitis·Xiangjun QianFengmin Lu
Jan 17, 2019·Cancers·Alessandro MussaGiovanni Battista Ferrero
May 5, 2020·Hepatology Communications·Injoon YeoYoungsoo Kim
Sep 17, 2019·Therapeutic Advances in Medical Oncology·Walid S AyoubShelly C Lu
Aug 9, 2020·International Journal of Nanomedicine·Kai WangXiaofei Liang
Jul 11, 2020·Therapeutic Advances in Gastroenterology·Boris J B Beudeker, Andre Boonstra
Jul 2, 2020·OncoTargets and Therapy·Yuwei LiShaoli Deng
Oct 6, 2020·BioMed Research International·Xueying WangJing Jiang
Feb 8, 2019·BMC Infectious Diseases·Tawatchai Apidechkul
Apr 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neehar D ParikhAnna S Lok
Nov 3, 2020·The Journal of International Medical Research·Ting SongYun Tian
Dec 11, 2020·Biomedicines·Yasi PanJun Yu
Dec 22, 2020·Human Pathology·Dauod ArifOyedele A Adeyi
Dec 20, 2019·The Journal of International Medical Research·Ting SongHao Wu
Jan 29, 2021·ESMO Open·Z CaiJ Liu
Oct 31, 2020·Journal of Hepatocellular Carcinoma·Miaoxia LiuJunqi Niu
Jan 10, 2021·International Journal of Molecular Sciences·Vijay PandyarajanJu Dong Yang
Mar 12, 2021·Expert Review of Gastroenterology & Hepatology·Yong-Sheng FangWei-Dong Du
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
May 1, 2021·Cancers·José D Debes On Behalf Of The Escalon Consortium
May 14, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yiming ChenWensheng Hu
Jun 22, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Toshihiko KobayashiHaku Ishida
Jul 2, 2021·Frontiers in Microbiology·Yuanyuan LiuThomas Tu
Aug 5, 2021·Journal of Gastrointestinal Cancer·Zihni Onur Uygun
Aug 10, 2021·World Journal of Gastroenterology : WJG·Ting LiuHui-Qing Jiang
Jul 4, 2020·Journal of Proteome Research·Qingqing WangGuowang Xu
Aug 29, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tung-Hung SuJia-Horng Kao
Aug 16, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aarshi VipaniJu Dong Yang
Sep 18, 2021·Hepatology Communications·Nia Adeniji, Renumathy Dhanasekaran
Oct 13, 2021·Technology in Cancer Research & Treatment·Bin Zheng MsDahong Zhang Md
Oct 30, 2021·Medicine·Jian-Ming ZhouKun-He Zhang
Oct 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Chenjun HuangChunfang Gao
Nov 6, 2021·Alimentary Pharmacology & Therapeutics·Elisabetta DegasperiPietro Lampertico
Oct 22, 2020·Liver Cancer·Jeong Hee YoonJung-Hwan Yoon
Dec 1, 2021·Hepatology International·Yuemin NanUNKNOWN Chinese Society of Hepatology, Chinese Medical Association