Longitudinal association between motor and obsessive compulsive symptoms in patients with psychosis and their unaffected siblings

European Archives of Psychiatry and Clinical Neuroscience
M SwetsGenetic Risk and Outcome of Psychosis (GROUP) Investigators

Abstract

Little is known about the co-prevalence of obsessive compulsive symptoms (OCS) and motor symptoms in patients with psychotic disorders. Cross-sectional associations between OCS and motor symptoms were assessed at baseline and at 3 years follow-up in patients (n = 726) with psychotic disorders and in their unaffected siblings (n = 761) from the Dutch Genetic Risk and Outcome of Psychosis (GROUP) study. Furthermore, longitudinal associations between changes in OCS and motor symptoms were evaluated. At baseline, OCS was not associated with any motor symptom (akathisia, dyskinesia, parkinsonism or dystonia) in patients. At follow-up, patients with OCS reported significantly more akathisia. Dividing the patients into four groups-no OCS, OCS remission with OCS only at baseline, OCS de novo with OCS only at follow-up and a persistent OCS group-revealed that the OCS de novo group already reported more akathisia at baseline compared to the no-OCS group. At follow-up, both the OCS de novo and the persistent OCS group reported more akathisia. These results remained significant after correcting for relevant confounders clozapine, GAF score, PANSS-negative score and IQ. Motor symptoms at baseline were significantly associated with OCS at fo...Continue Reading

References

Jun 1, 1990·Archives of General Psychiatry·J K WingN Sartorius
May 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·T R Barnes
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Feb 1, 1989·The American Journal of Psychiatry·S E SwedoE R Wald
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·P Martínez-MartínF Bermejo
Mar 4, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·S KrügerJ Langkrär
Apr 12, 2000·Journal of Psychiatric Research·P TibboL Warneke
May 23, 2001·Psychiatry Research·M PoyurovskyA Weizman
Jan 10, 2003·Psychiatry and Clinical Neurosciences·Masayuki OhtaYoshio Morita
Aug 21, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Alex F MaiaEuripedes C Miguel
May 4, 2004·Biological Psychiatry·Damiaan DenysHerman G M Westenberg
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jun 22, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David M GardnerPaul Waraich
Nov 25, 2006·Schizophrenia Research·Levent SevincokFiliz Kokcu
Apr 14, 2007·The Journal of Neuropsychiatry and Clinical Neurosciences·Michael PoyurovskyAbraham Weizman
Oct 17, 2007·Brain & Development·Paul J Lombroso, Lawrence Scahill
Oct 13, 2009·Psychological Medicine·D D PatelN A Fineberg
May 12, 2010·The Journal of Nervous and Mental Disease·Karen E AndersonUNKNOWN Huntington's Study Group
Jan 29, 2011·Biological Psychiatry·Martijn FigeeDamiaan Denys
Jul 21, 2012·Neuropsychobiology·Sebastian Walther, Werner Strik
May 21, 2014·Nature Reviews. Neuroscience·David L PaulsDaniel A Geller
Sep 5, 2014·JAMA Psychiatry·Sandra M MeierPreben B Mortensen
Nov 27, 2014·The Journal of Nervous and Mental Disease·Georg JuckelParaskevi Mavrogiorgou
Dec 2, 2014·International Journal of Colorectal Disease·Kristiina KyrklundRisto J Rintala
Feb 18, 2015·Journal of the International Neuropsychological Society : JINS·Franziska MaierLars Timmermann
Dec 19, 2016·European Archives of Psychiatry and Clinical Neuroscience·Frederike SchirmbeckUNKNOWN GROUP investigators

❮ Previous
Next ❯

Citations

Jun 27, 2019·European Archives of Psychiatry and Clinical Neuroscience·Dusan HirjakRobert Christian Wolf
Mar 8, 2020·European Archives of Psychiatry and Clinical Neuroscience·Andrea SchmittPeter Falkai
Oct 24, 2020·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller

❮ Previous
Next ❯

Software Mentioned

Statistical package for Social Sciences ( SPSS
GROUP

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here