Longitudinal association of hemostatic factors with risk for cancers of the breast, colorectum, and lung among postmenopausal women

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Geoffrey C KabatThomas E Rohan

Abstract

The aim of this study was to examine whether hemostatic factors associated with coagulation and inflammation pathways are associated with cancer risk in postmenopausal women. We used data from the Women's Health Initiative study to examine the association of plasma fibrinogen levels, factor VII antigen activity, and factor VII concentration measured at baseline and during follow-up with the risk for cancers of the breast, colorectum, and lung. Among 5287 women who were followed up for a median of 11.4 years, 275 cases of breast cancer, 102 cases of colorectal cancer, and 90 cases of lung cancer were identified. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals for the association of hemostatic factors with each cancer. Hemostatic factors were not associated with breast cancer in either baseline or longitudinal analyses. Baseline hemostatic factors showed weak associations with colorectal cancer; however, no association was seen in longitudinal analyses. Fibrinogen was positively associated with lung cancer in both baseline and longitudinal analyses; the association was seen only in never and former smokers, not in current smokers. We found no evidence of an association between hemo...Continue Reading

References

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Citations

Jun 24, 2017·American Journal of Epidemiology·Deirdre K TobiasSamia Mora
Apr 25, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mirja GrafetstätterTilman Kuehn
Dec 3, 2020·Critical Reviews in Oncology/hematology·Nathalie MichelsInge Huybrechts
Aug 2, 2020·Thrombosis Research·Marina Marchetti, Anna Falanga

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