Longitudinal Associations Between Preschool Disruptive Mood Dysregulation Disorder Symptoms and Neural Reactivity to Monetary Reward During Preadolescence

Journal of Child and Adolescent Psychopharmacology
Ellen M KesselDaniel N Klein

Abstract

Reward-processing abnormalities are thought to be a key feature of various psychiatric disorders and may also play a role in disruptive mood dysregulation disorder (DMDD), a new diagnosis in DSM-5. In the current study, we used event-related potentials (ERP) sensitive to monetary gains (i.e., the reward positivity [RewP]) and losses (i.e., the N200) to examine associations between symptoms of DMDD during early childhood and later reward processing during preadolescence. To assess early emerging DMDD symptoms in a large longitudinal community sample (n=373) of 3-year old children, we administered a diagnostic interview, Preschool Age Psychiatric Assessment (PAPA) with parents. At a later assessment, ∼6 years later, children completed a monetary reward task while an electroencephalogram (EEG) was recorded. Children's lifetime history of psychopathology was also assessed at that time using Kiddie-Schedule of Affective Disorders and Schizophrenia (K-SADS) with the child and parent. Multiple regression analyses revealed that age 3 DMDD symptoms predicted an enhanced RewP to monetary rewards in preadolescence. This association is independent of demographics and lifetime history of symptoms of depression, any anxiety disorder, attenti...Continue Reading

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Citations

Aug 25, 2016·Journal of Affective Disorders·Erica MeyersAmy Krain Roy
Jan 11, 2017·Psychophysiology·Amanda R LevinsonGreg Hajcak
Mar 24, 2016·Journal of Child and Adolescent Psychopharmacology·Gabrielle A Carlson
May 10, 2017·Annual Review of Clinical Psychology·Melissa A BrotmanEllen Leibenluft
Oct 18, 2018·Developmental Psychobiology·Christen M DeveneyLauren S Wakschlag
Jan 20, 2021·Developmental Psychobiology·Maria Kryza-LacombeJillian L Wiggins
Jul 1, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Jillian Lee WigginsLauren S Wakschlag
Mar 3, 2018·Journal of the American Academy of Child and Adolescent Psychiatry·Jillian Lee WigginsLauren S Wakschlag
Apr 16, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Franziska GillerChristian Beste
Jun 1, 2021·Child and Adolescent Psychiatric Clinics of North America·Ellen M KesselDaniel N Klein
Jul 8, 2021·European Child & Adolescent Psychiatry·Ines Mürner-LavanchyJulian Koenig
Jul 13, 2021·Journal of Experimental Child Psychology·Kiera M JamesBrandon E Gibb
Aug 10, 2021·Development and Psychopathology·Brendan OstlundKoraly E Pérez-Edgar
Jan 4, 2022·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer PachecoStacia R Friedman-Hill

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