Longitudinal Associations between Survival in Alzheimer's Disease and Cholinesterase Inhibitor Use, Progression, and Community-Based Services

Dementia and Geriatric Cognitive Disorders
Carina WattmoLennart Minthon

Abstract

Factors including rate of disease progression, different aspects of cholinesterase inhibitor (ChEI) treatment, and use of community-based services might affect the longitudinal outcome of Alzheimer's disease (AD). Whether these factors alter life expectancy in AD is unclear. We therefore examined the association between long-term ChEI therapy and survival. The present study included 1,021 patients with a clinical diagnosis of AD and a Mini-Mental State Examination score of 10-26 at baseline from a 3-year, prospective, multicenter study of ChEI therapy in clinical practice. The relationship of potential predictors with mortality was analyzed using Cox regression models. After up to 16 years of follow-up, 841 (82%) of the participants had died. In the Alzheimer's Disease Assessment Scale-cognitive subscale, a mean decline of ≥ 4 points/year or ≥ 2 points/year on the Physical Self-Maintenance Scale was a risk factor for an earlier death. In the multivariate models, longer survival was associated with higher ChEI dose and longer duration of treatment. Users of community-based services at baseline exhibited a 1-year shorter mean life expectancy than nonusers. A longer survival time can be anticipated for AD patients with slower dete...Continue Reading

Citations

Feb 21, 2018·Alzheimer's Research & Therapy·Hanneke F M Rhodius-MeesterWiesje M van der Flier
Jul 25, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Sandipan BhattacharjeeWilliam J Burke
Sep 14, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Simona HapcaPeter T Donnan
May 11, 2018·American Journal of Alzheimer's Disease and Other Dementias·Jakub KazmierskiMagda Tsolaki
Sep 17, 2019·Journal of Alzheimer's Disease : JAD·Miika LinnaTero Ylisaukko-Oja

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