Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation

Acta Ophthalmologica
Markus LenzhoferHerbert A Reitsamer

Abstract

Like the classic trabeculectomy, the minimally invasive, ab interno XEN Glaucoma Gel Microstent (XEN-GGM) creates a filtration bleb in the conjunctiva. The goal of this study was to investigate internal bleb morphology over time with anterior segment optical coherence tomography (AS-OCT) after XEN-GGM implantation. In a prospective, single-centre, single-armed cohort study, blebs were characterized using AS-OCT in 78 eyes of 60 patients at day 1, at weeks 1 and 2 and at months 1, 3, 6, 9 and 12 after XEN-GGM implantation in patients with open-angle glaucoma. Morphological bleb characteristics were correlated with IOP and surgical success. Anterior segment optical coherence tomography data indicate early and late bleb changes in the course of 12 months. Uniform blebs in AS-OCTs showed higher IOPs at all examinations between week 1 (17.7 ± 4.8 mmHg versus 11.3 ± 7.1 mmHg, p = 0.001) and month 3 (16.4 ± 6.1 versus 13.4 ± 6.1, p = 0.04). Subconjunctival tissue separation bleb morphology was associated with lower mean IOPs during the course of 12 months (r = -0.75, p = 0.031). Predictors for surgical failure at month 12 were microcystic multiform bleb morphology in AS-OCT at month 3 (60% versus 15%, relative risk 4.0, p = 0.043) and...Continue Reading

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Citations

Feb 13, 2020·Journal of Cataract and Refractive Surgery·Antonio M FeaFrancesco Oddone
Mar 25, 2020·Journal of Glaucoma·Carlo Alberto CutoloCarlo Enrico Traverso
Sep 9, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Markus LenzhoferHerbert A Reitsamer
Sep 17, 2020·Annual Review of Vision Science·David J Mathew, Yvonne M Buys
May 18, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matteo SacchiLeonardo Mastropasqua
Mar 7, 2020·Journal of Cataract and Refractive Surgery·Antonio M FeaFrancesco Oddone
Apr 29, 2021·European Journal of Ophthalmology·Néstor Ventura-AbreuMarta Pazos
Jul 13, 2021·Acta Ophthalmologica·John Tsia-Chuen KanBryan Chin Hou Ang

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Software Mentioned

OCT
pasw
statxact
SPSS Statistics
StatSoft
AS

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