Longitudinal Brain Changes Associated with Prophylactic Cranial Irradiation in Lung Cancer

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
M SimóA Rodríguez-Fornells

Abstract

The toxic effects of prophylactic cranial irradiation (PCI) and platinum-based chemotherapy on cognition in the lung cancer population have not yet been well established. In the present study we examined the longitudinal neuropsychological and brain structural changes observed in patients with lung cancer who were undergoing these treatments. Twenty-two patients with small cell lung cancer (SCLC) who underwent platinum-based chemotherapy and PCI were compared with two control groups: an age- and education-matched group of healthy controls (n = 21) and a group of patients with non-SCLC (NSCLC, n = 13) who underwent platinum-based chemotherapy. All groups were evaluated using a neuropsychological battery and multimodal structural magnetic resonance imaging: T1-weighted and diffusion tensor imaging at baseline (before PCI for SCLC and chemotherapy for NSCLC) and at 3 months after treatment. T1 voxel-based morphometry and tract-based spatial statistics were used to analyze microstructural changes in gray matter (GM) and white matter (WM). The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core Questionnaire was also completed. Patients with SCLC exhibited cognitive deterioration in verbal f...Continue Reading

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Citations

Sep 11, 2020·European Journal of Cancer Care·Noorazrul Yahya, Hanani A Manan
Mar 16, 2017·Brain Imaging and Behavior·M SimóAntoni Rodríguez-Fornells
Aug 12, 2017·Computational and Mathematical Methods in Medicine·Konstantinos BromisVasileios Kouloulias
Oct 26, 2018·Frontiers in Oncology·Tyler P Robin, Chad G Rusthoven
Dec 10, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lucía VaqueroMarta Simó
Jan 7, 2021·Brain Topography·Anastasios MentzelopoulosGeorge K Matsopoulos
Jun 25, 2019·NeuroImage. Clinical·F BartelUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 27, 2021·World Journal of Clinical Oncology·Felipe CouñagoFrancesc Casas
Aug 18, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brenna C McDonald

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