Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)

Journal of Magnetic Resonance Imaging : JMRI
Yan ZhangYi Wang

Abstract

To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001). MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.

References

Nov 1, 1995·Annals of Neurology·W BrückH Lassmann
Mar 30, 2004·Annals of Neurology·Michael H Barnett, John W Prineas
Feb 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·E Mark HaackeRobert I Grossman
Dec 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ludovic de RochefortYi Wang
Jun 24, 2011·Journal of Magnetic Resonance Imaging : JMRI·Stefan RopeleFranz Fazekas
Jun 29, 2011·Annals of Neurology·María I GaitánDaniel S Reich
Dec 16, 2011·Brain : a Journal of Neurology·Francesca BagnatoJeff H Duyn
Mar 13, 2012·Journal of Magnetic Resonance Imaging : JMRI·Jesper HagemeierRobert Zivadinov
May 26, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·David PalingXavier Golay
May 30, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Wei BianDaniel Pelletier
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dmitriy A YablonskiyAnne H Cross
Jan 26, 2013·Magnetic Resonance Imaging·Francesca BagnatoEdward Brian Welch
Jun 14, 2013·Neurology·Vanessa WiggermannAlexander Rauscher
Feb 11, 2014·Handbook of Clinical Neurology·Alexandra Kutzelnigg, Hans Lassmann
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi Wang, Tian Liu
Aug 20, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cynthia WisnieffDavid Pitt

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Citations

Apr 2, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Petr DusekJan Aaseth
Dec 3, 2016·NMR in Biomedicine·Sarah Eskreis-WinklerYi Wang
Apr 15, 2017·AJNR. American Journal of Neuroradiology·M CastellaroM Calabrese
Oct 13, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhe LiuYi Wang
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Oct 25, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Anne KerbratGilles Edan
Sep 9, 2017·IEEE Transactions on Bio-medical Engineering·Youngwook KeeYi Wang
Dec 19, 2018·Brain : a Journal of Neurology·Ulrike W KaunznerSusan A Gauthier
Dec 18, 2018·Recent Patents on Biotechnology·Feng LinYi Wang
Jan 18, 2020·Journal of Magnetic Resonance Imaging : JMRI·Selvadasan VinayagamaniChandrasekharan Kesavadas
Aug 19, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rong GuoZhi-Pei Liang
Mar 16, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yi WangMartin R Prince
Sep 10, 2019·The Journal of Clinical Investigation·Nathanael J LeeDaniel S Reich
Aug 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhe LiuYi Wang
Jun 14, 2017·Therapeutic Advances in Neurological Disorders·Ulrike W Kaunzner, Susan A Gauthier
Aug 6, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pascal SpincemailleYi Wang
Oct 19, 2020·NeuroImage·Elizabeth M SweeneySusan A Gauthier
Feb 28, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·José P MarquesFerdinand Schweser
Apr 8, 2019·Magnetic Resonance Imaging·Shun ZhangYi Wang
May 25, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yan WenYi Wang
Dec 5, 2017·NeuroImage. Clinical·Jesper HagemeierRobert Zivadinov
Sep 5, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Alexey V DimovYi Wang
Apr 10, 2020·Multiple Sclerosis and Related Disorders·Sanjeev ChawlaIlya Kister

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